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Investigación
Biología Celular
Líneas de investigación
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Biología Celular
a) Investigación propia:
- "Regulación funcional del activador de Ras: hSos1"
- "Señalización diferencial de las proteínas Ras"
- "Estudio sobre el mecanismo de activación de las proteínas Ras por prostaglandinas ciclopentenonas (15dPGJ2 y PGA1) y su repercusiones en el desarrollo tumoral".
- "Mecanismo de actuación molecular de las proteínas docking/scaffold: Spry/Spred y Sur8".
b) Investigación en colaboración:
- En colaboración con el grupo del Dr. Alberto Muñoz (IIB, Madrid), hemos investigado el mecanismo de actuación del agente anti-cancerígeno Plitidepsin® y el papel de Spry2 en cáncer de colon.
- En colaboración con el grupo de la Dra. Marian Martínez-Balbás (Parc Científic, Barcelona) hemos analizado los efectos de H- y N-Ras oncogénico sobre las histonas acetil-transferasas: CBP/p300.
- En colaboración con el grupo del Dr. Eugenio Santos (CIC, Salamanca), hemos estudiado la regulación funcional de Sos1 y Spry2 por el complejo COP9/Signalosoma.
- En colaboración con los grupos de los Doctores George Thomas y Ramón Salazar (ICO, IDIBELL, Barcelona), estamos investigando la relevancia de las proteínas "docking/scaffold" Spry2 y Sur8, como posibles dianas en cáncer de colon.
- En colaboración con los grupos de los Doctores Xosé Bustelo (CIC, Salamanca) y Pedro Fernández Salguero (UEX, Badajoz), estamos estudiando el papel funcional de Sur8 en la homeostasis de la piel.
Proyectos de investigación
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Proyectos durante los 5 últimos años
Título: Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
Entidad Financiadora: ISCIII (CB16/12/00273)
Duración: 2017 hasta: 2019
Investigador Principal: Alberto Muñoz Terol
Dotación Económica: 35.005,00 € / año
Título: New therapeutic strategies for resistant colorectal cancer
Entidad Financiadora: Fundación Científica de la AECC
Duración: 2015 hasta: 2021
Investigador Principal (Coordinador): George Thomas
Co-Investigador Principal (Grupo 2): Ramón Salazar Soler
Co-Investigador Principal (Grupo 3): José María Rojas Cabañeros
Dotación Económica Global: 1.200.000,00 €
Dotación Económica Grupo 3: 335.000,00 €
Título: Papel fisiológico de la proteína Shoc2/Sur8 y estudio de su implicación en patologías humanas
Entidad Financiadora: MINECO (SAF2016-78852-R)
Duración: 2017 hasta: 2019
Investigador Principal: José María Rojas Cabañeros
Dotación Económica: 278.300,00 €
Título: Papel de Spry2 y Sur8 en cáncer colorrectal
Entidad Financiadora: AESI 2020 (PI20CIII/00029)
Duración: 2021 hasta: 2024
Investigador Principal: José María Rojas Cabañeros
Co-Investigador Principal: Berta Ana Félez
Dotación económica: 177.000,00€
Título: Shoc2 as potential molecular target against lung cancer: A preclinical study
Entidad financiadora: Fundación Universidad Alfonso X El Sabio (FUAX)
Duración: 2025 hasta: 2027
Investigador Principal: Daniel Peña Jiménez
Dotación económica: 50.000,00 €
Publicaciones destacadas
Aβ42 Peptide Promotes Proliferation and Gliogenesis in Human Neural Stem Cells
Aβ42 Peptide Promotes Proliferation and Gliogenesis in Human Neural Stem Cells. Bernabeu-Zornoza A, Coronel R, Palmer C, Calero M, Martínez-Serrano A, Cano E, Zambrano A, Liste I. Mol Neurobiol. 2019 Jun;56(6):4023-4036. doi: 10.1007/s12035-018-1355-7. Epub 2018 Sep 27. PMID: 30259399.
PUBMED DOIReduced Salivary Lactoferrin Levels in Early-Onset Alzheimer's Disease
Antequera D, Carrero L, Gonzalez-Sanchez M, Cantero JL, Orive G, Municio C, Carro E. Reduced Salivary Lactoferrin Levels in Early-Onset Alzheimer's Disease. Aging Dis. 2024 May 7;15(3):945-947. doi: 10.14336/AD.2023.0819.
DOIImmune profiling of gliomas reveals a connection with Tau function and the tumor vasculature
Cejalvo T*, Gargini R*, Segura-Collar B, Mata P, Herránz B, Cantero D, Ruano Y, García-Pérez D, Pérez-Núñez A, Ramos A, Hernández-Laín A, Cruz Martín-Soberón M, Sánchez-Gómez P# and Sepúlveda-Sánchez JM# (# Co-corresponding author) (* Co-1st author). (2020) Immune profiling of gliomas reveals a connection with Tau function and the tumor vasculature. Cancers. 12-11, pp.E3230. PMID: 33147752doi: 10.3390/cancers12113230
DOIEuropean mitochondrial DNA haplogroups and metabolic disorders in HIV/HCV-coinfected patients on highly active antiretroviral therapy
European mitochondrial DNA haplogroups and metabolic disorders in HIV/HCV-coinfected patients on highly active antiretroviral therapy. Micheloud D, Berenguer J, Guzmán-Fulgencio M, Campos Y, García-Álvarez M, Catalán P, Cosín J, Miralles P, López JC, Resino S.J Acquir Immune Defic Syndr. 2011 ; 58:371-8. DOI: 10.1097/QAI.0b013e31822d2629
DOIEuropean mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients
European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients. García-Álvarez M, Guzmán-Fulgencio M, Berenguer J, Micheloud D, Campos Y, López JC, Cosín J, Miralles P, Alvarez E, Resino S. AIDS. 2011;25:1619-926. DOI: 10.1097/QAD.0b013e328349820f
DOINeurogenesis is increased in human neural stem cells by Aβ40 peptide
Bernabeu-Zornoza, A.; Coronel, R.; Palmer, C.; Martín, A.; López-Alonso, V.; Liste, I. (2022). Neurogenesis is increased in human neural stem cells by Aβ40 peptide. Int J Mol Sci. 23, 5820. doi: 10.3390/ijms23105820.
DOIToxicity of nanoplastics for zebrafish embryos, what we know and where to go next
Torres-Ruiz M*, De la Vieja A, Gonzalez MD, Lopez ME, Castaño-Calvo A, Cañas-Portilla AI. Toxicity of nanoplastics for zebrafish embryos, what we know and where to go next. Science of the Total Environment 2021 797:149125. PMID: 34346375. doi: 10.1016/j.scitotenv.2021.149125
DOIColocalization Analysis of Peripheral Myelin Protein-22 and Lamin-B1 in the Schwann Cell Nuclei of Wt and TrJ Mice
Di Tomaso MV, Vázquez Alberdi L, Olsson D, Cancela S, Fernández A, Rosillo JC, Reyes Ábalos AL, Álvarez Zabaleta M, Calero M, Kun A. Colocalization Analysis of Peripheral Myelin Protein-22 and Lamin-B1 in the Schwann Cell Nuclei of Wt and TrJ Mice. Biomolecules. 2022 12(3):456. doi: 10.3390/biom12030456.
DOIThe transcription factor LEF1 interacts with NFIX and switches isoforms during adult hippocampal neural stem cell quiescence
Garcia-Corzo L, Calatayud-Baselga I, Casares-Crespo L, Mora-Martinez C, Julian Escribano-Saiz J, Hortiguela R, et al. The transcription factor LEF1 interacts with NFIX and switches isoforms during adult hippocampal neural stem cell quiescence. Front Cell Dev Biol. 2022;10:912319. Q1
ΔNp73 and its effector targets promote colorectal peritoneal carcinosis and predict survival. The Journal of Pathology.
Pastor-Morate D, Amigo-Morán L, Garranzo-Asensio M, Rejas-González R, Carnicero P, Rodríguez N, Pérez-Robledo JP, Barderas R, Prieto-Nieto I, Domínguez G. ΔNp73 and its effector targets promote colorectal peritoneal carcinosis and predict survival. The Journal of Pathology. 2024;263:328.
DOIRegulation of CBP andTip60 coordinates histone acetylation at local and global level during Ras-induced transformation
Sánchez-Molina S, Estarás C, Oliva JL, Akizu N, Asensio-Juan E, Rojas JM & Martínez-Balbás MA. Regulation of CBP andTip60 coordinates histone acetylation at local and global level during Ras-induced transformation. Carcinogenesis 2014; 35(10):2194-202. doi:10.1093/carcin/bgu111
DOIEstablishment and characterization of a rainbow trout heart endothelial cell line with susceptibility to viral hemorrhagic septicemia virus (VHSV) Fish Shellfish
A Luque; A González-Granja; L González; C Tafalla. 2014. Establishment and characterization of a rainbow trout heart endothelial cell line with susceptibility to viral hemorrhagic septicemia virus (VHSV) Fish Shellfish Immunol. 2014 May;38(1):255-64. https://doi.org/10.1016/j.fsi.2014.03.027.
DOIRole of Amyloid Precursor Protein (APP) and Its Derivatives in the Biology and Cell Fate Specification of Neural Stem Cells
Coronel R, Bernabeu-Zornoza A, Palmer C, Muñiz-Moreno M, Zambrano A, Cano E, Liste I. Mol Neurobiol. 2018 Sep;55(9):7107-7117. doi: 10.1007/s12035-018-0914-2. Epub 2018 Jan 30. PMID: 29383688
PUBMED DOIEpigenetic silencing of OR and TAS2R genes expression in human orbitofrontal cortex at early stages of sporadic Alzheimer's disease
Alves VC, Figueiro-Silva J, Ferrer I, Carro E. Epigenetic silencing of OR and TAS2R genes expression in human orbitofrontal cortex at early stages of sporadic Alzheimer's disease. Cell Mol Life Sci. 2023 Jul 5;80(8):196. doi: 10.1007/s00018-023-04845-1.
DOISynthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors
Castaño T, Wang H, Campillo NE, Ballester S, González-García C, Hernández J, Pérez C, Cuenca J, Pérez-Castillo A, Martínez A, Huertas O, Gelpí JL, Luque FJ, Ke H and Gil C. Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors. ChemMedChem. (2009) 4-5, pp.866-876.PMCID: PMC2952885 doi:10.1002/cmdc.200900043
PUBMED DOICellular plasticity and tumor microenvironment in gliomas: the struggle to hit a moving target
Gargini R, Segura-Co llar B, Sánchez-Gómez P. (2020) Cellular plasticity and tumor microenvironment in gliomas: the struggle to hit a moving target. Cancers. 12(6): E1622. PMID: 32570988 doi: 10.3390/cancers12061622
DOIOligomeric and fibrillar species of Aβ42 diversely affect human neural stem cells
Bernabeu-Zornoza, A.; Coronel, R.; Palmer, C.; López-Alonso, V.; Liste, I. (2021). Oligomeric and fibrillar species of Aβ42 diversely affect human neural stem cells. Int J Mol Sci. 22, 9537. doi: 10.3390/ijms22179537.
DOIRadio-Iodide Treatment: From Molecular Aspects to the Clinical View
De la Vieja A* and Riesco-Eizaguirre G. Radio-Iodide Treatment: From Molecular Aspects to the Clinical View. Cancers 2021 13(5):995. PMID: 33673669. doi: 10.3390/cancers13050995
DOIBlood DNAMethylation Patterns in Older Adults With Evolving Dementia
Pérez RF, Alba-Linares JJ, Tejedor JR, Fernández AF, Calero M, Román-Domínguez A, Borrás C, Viña J, Ávila J, Medina M, Fraga MF. Blood DNAMethylation Patterns in Older Adults With Evolving Dementia. J Gerontol A Biol Sci Med Sci. 2022 77(9):1743-1749. doi: 10.1093/gerona/glac068.
DOIPrevalence and Population Diversity of Listeria monocytogenes Isolated from Dairy Cattle Farms in the Cantabria Region of Spain
Varsaki A, Ortiz S, Santorum P, López P, López-Alonso V, Hernández M, Abad D, Rodríguez-Grande J, Ocampo-Sosa AA, Martínez-Suárez JV. Prevalence and Population Diversity of Listeria monocytogenes Isolated from Dairy Cattle Farms in the Cantabria Region of Spain. Animals (Basel). 2022 Sep 19;12(18):2477. Q1
Functional Proteomics Characterization of the Role of SPRYD7 in Colorectal Cancer Progression and Metastasis
Montero-Calle A, Jiménez de Ocaña S, Benavente-Naranjo R, Rejas-González R, Bartolomé RA, Martínez-Useros J, Sanz R, Dziaková J, Fernández-Aceñero MJ, Mendiola M, et al. Functional Proteomics Characterization of the Role of SPRYD7 in Colorectal Cancer Progression and Metastasis. Cells. 2023; 12:2548.
DOIShoc2/Sur8 protein regulates neurite outgrowth
León G, Sánchez-Ruiloba L, Perez-Rodriguez A, Gragera T, Martinez N, Hernandez S, Anta B, Calero O, Garcia-Domínguez CA, Dura LM, Peña-J Jimenez D, Castro J, Zarich N, Sanchez-Gomez P, Calero M, Iglesias T, Oliva JL & Rojas JM. Shoc2/Sur8 protein regulates neurite outgrowth. PloS ONE. 2014; 9(12):e114837. doi:10.1371/journal.pone.0114837
DOIBeta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism
Zovein AC, Luque A, Turlo KA, Hofmann JJ, Yee KM, Becker MS, Fassler R, Mellman I, Lane TF, Iruela-Arispe ML. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev Cell. 2010 Jan 19;18(1):39-51. Los dos mpriemros autores han contribuido igualmente en este trabajo. doi: 10.1016/j.devcel.2009.12.006.
DOIEffects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids
Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids. Magro-Lopez E, Palmer C, Manso J, Liste I, Zambrano A. Stem Cell Res Ther. 2018 Jul 11;9(1):186. doi: 10.1186/s13287-018-0943-9. PMID: 29996941; PMCID: PMC6042463.
PUBMED DOISalivary Lactoferrin Expression in a Mouse Model of Alzheimer's Disease
Antequera D, Moneo D, Carrero L, Bartolome F, Ferrer I, Proctor G, Carro E. Salivary Lactoferrin Expression in a Mouse Model of Alzheimer's Disease. Front Immunol. 2021 Sep 30;12:749468. doi: 10.3389/fimmu.2021.749468.
DOIBeta interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells
Martín-Saavedra FM, González-García C, Bravo B and Ballester S. Beta interferon restricts the inflammatory potential of CD4+ cells through the boost of the Th2 phenotype, the inhibition of Th17 response and the prevalence of naturally occurring T regulatory cells. Molecular Immunology (2008)45-15, pp.4008-4019. ISSN 0161-5890 doi:10.1016/j.molimm.2008.06.006
PUBMED DOIThe IDH-Tau-EGFR triad defines the neovascular landscape of diffuse gliomas by controlling mesenchymal differentiation
Gargini R*, Segura-Collar B*, Hernández-SanMiguel E, Garcia-Escudero V, Romero-Bravo A, Herránz B, Núñez FJ, Cantero D, García-Pérez D, Ayuso-Sacido A, Seoane J, Sepúlveda-Sánchez JM, Hernández-Laín A, Castro MG, García-Escudero R, Ávila J* and Sánchez-Gómez P*. (* Co-corresponding author) (* Co-1st author) (2020) The IDH-Tau-EGFR triad defines the neovascular landscape of diffuse gliomas by controlling mesenchymal differentiation. Sci. Transl. Med.12 (527). PMID: 31969485 doi: 10.1126/scitranslmed.aax1501
DOIAβ42 peptide promotes proliferation and gliogenesis in human neural stem cells
Bernabeu-Zornoza, A.; Coronel, R.; Palmer, C.; Calero, M.; Martínez-Serrano, A.; Cano, E.; Zambrano, A.; Liste, I. (2019). Aβ42 peptide promotes proliferation and gliogenesis in human neural stem cells. Mol Neurobiol. 56, 4023-4036. doi: 10.1007/s12035-018-1355-7.
DOIDiagnostic accuracy of cerebrospinal fluid biomarkers in genetic prion diseases
Schmitz M, Villar-Piqué A, Hermann P, Escaramís G, Calero M, Chen C, Kruse N, Cramm M, Golanska E, Sikorska B, Liberski PP, Pocchiari M, Lange P, Stehmann C, Sarros S, Martí E, Baldeiras I, Santana I, Žáková D, Mitrová E, Dong XP, Collins S, Poleggi A, Ladogana A, Mollenhauer B, Kovacs GG, Geschwind MD, Sánchez-Valle R, Zerr I, Llorens F. Diagnostic accuracy of cerebrospinal fluid biomarkers in genetic prion diseases. Brain. 2022 145(2):700-712. doi: 10.1093/brain/awab350.
DOIAnchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
TT Chen; A Luque; S Lee; SM Anderson; T Segura; ML Iruela-Arispe. 2010. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol. 2010 Feb 22;188(4):595-609. https://doi.org/10.1083/jcb.200906044.
DOINeurogenesis Is Increased in Human Neural Stem Cells by A40 Peptide
Bernabeu-Zornoza A, Coronel R, Palmer C, Lopez-Alonso V, Liste I. Neurogenesis Is Increased in Human Neural Stem Cells by A40 Peptide. Int. J. Mol. Sci. 2022, 23, 5820. Q1
Metabolic Reprogramming Helps to Define Different Metastatic Tropisms in Colorectal Cancer
Montero-Calle A, Gomez de Cedron M, Quijada-Freire A, Solís-Fernandez G, López-Alonso V, Espinosa-Salinas I, Pelaez-García A, Fernandez-Aceñero MJ, Ramírez de Molina A, Barderas R. Metabolic Reprogramming Helps to Define Different Metastatic Tropisms in Colorectal Cancer. Front. Oncol. 2022; 12
DOISPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150
Barbáchano A, Fernández-Barral A, Pereira F, Segura MF, Ordóñez-Morán P, Carrillo-de Santa Pau E, González-Sancho JM, Hanniford D, Martínez N, Costales-Carrera A, Real FX, Pálmer HG, Rojas JM, Hernando E & Muñoz A. SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150. Oncogene. 2016; 35(23):2991-3003. doi:10.1038/onc.2015.366
DOIRadio-Iodide Treatment: From Molecular Aspects to the Clinical View
Gutiérrez-Salmerón M, García-Martínez JM, Martinez-Useros J, Fernandez-Aceñedo MJ, Viollet B, Olivier S, Chauha J, Lucena SR, De la Vieja A, Goding CR and Chocarro-Calvo A* and García-Jiménez C*. Paradoxical activation of AMPK by glucose drives selective EP300 activity in colorectal cancer. Plos Biology 2020 6: e3000732. PMID 32603375. DOI: 10.1371/journal.pbio.3000732
PUBMED DOIAmyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer's disease experimental models
de la Cueva M, Antequera D, Ordoñez-Gutierrez L, Wandosell F, Camins A, Carro E, Bartolome F. Amyloid-β impairs mitochondrial dynamics and autophagy in Alzheimer's disease experimental models. Sci Rep. 2022 Jun 16;12(1):10092. doi: 10.1038/s41598-022-13683-3.
DOIBeta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis
Martín-Saavedra FM, Flores N, Dorado B, Eguiluz C, Bravo B, García-Merino A and Ballester S. Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis. Molecular immunology (2007) 44-14, pp.3597-3607. ISSN 0161-5890 doi:10.1016/j.molimm.2007.03.002
PUBMED DOIThe EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas
Segura-Collar B, Gargini R, Tovar-Ambel E, Hernández-SanMiguel E, Epifano C, Pérez de Castro I, Hernández-Laín A, Casas-Tintó S, Sánchez-Gómez P. (2020) The EGFR-TMEM167A-p53 Axis Defines the Aggressiveness of Gliomas. Cancers 12(1):208. PMID: 31947645 doi: 10.3390/cancers12010208
DOINeuronal and glial differentiation of human neural stem cells is regulated by amyloid precursor protein (APP) levels
Coronel, R.; Lachgar, M.; Bernabeu-Zornoza, A.; Palmer, C.; Domínguez-Alvaro, M.; Revilla, A.; Ocaña, I.; Fernández, A.; Martínez-Serrano, A.; Cano, E.; Liste, I. (2019). Neuronal and glial differentiation of human neural stem cells is regulated by amyloid precursor protein (APP) levels. Mol Neurobiol. 56, 1248-1261. doi: 10.1007/s12035-018-1167-9.
DOISurvival Patterns of Human Prion Diseases in Spain, 1998-2018: Clinical Phenotypes and Etiological Clues
Tejedor-Romero L, López-Cuadrado T, Almazán-Isla J, Calero M, García López FJ, de Pedro-Cuesta J. Survival Patterns of Human Prion Diseases in Spain, 1998-2018: Clinical Phenotypes and Etiological Clues. Front Neurosci. 2022 15:773727. doi: 10.3389/fnins.2021.773727.
DOIContent with Investigacion .
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Jose María Rojas Cabañeros
Jefe de la Unidad de Biología Celular - Profesor de Investigación de OPIs
ORCID code: 0000-0002-7547-2825
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List of staff