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Investigación
Endotelio Funcional
Líneas de investigación
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Endotelio Funcional
Nuestro objetivo principal es estudiar la funcionalidad del sistema endotelial como herramienta diagnóstica y terapéutica en diferentes patologías humanas principalmente del sistema respiratorio.
Líneas de investigación. (1) Contribución del sistema vascular a enfermedades pulmonares mediadas por trastornos inflamatorios o focos de fibrosis. (2) Evaluación y regulación de la transición endotelio-mesénquima e implicación patológica. (3) Efecto de la contaminación ambiental sobre la fisiología pulmonar. (4) Reprogramación endotelial hacia iPS. (5) Papel de las células endoteliales en regeneración tisular.
Proyectos de investigación
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Proyectos como Investigador Principal.
- “Mecanismos endoteliales implicados en la protección, reparación y regeneración tisular tras alteraciones inflamatorias o fibrosis en enfermedades respiratorias raras”. 2019-2023. FIS, PI18CIII/00040 (IERPY-M 389/18).
- “Contribución del endotelio vascular a la patología inflamatoria y fibrótica en las enfermedades pulmonares raras”. 2016-2018. FIS, PI15CIII/00044 (IERPY 1149/16).
- “Regulation of the polarization of tumor associated macrophages by the ARF gene and its functionality on tumor angiogenesis”. 2013-2016. Instituto Salud Carlos III. TPY-M 1068/13.
Proyectos como Investigador Colaborador.
- “Estudio de la contribución de la microbiota, el metabolismo y la inmunidad innata a la aparición y progresión de las enfermedades pulmonares intersticiales”. 2023-2024. AESI IERPY-M 308/20 (PI20CIII/00018).
- “Impulso de investigación del sistema inmune en la resistencia de las terapias antitumorales”. 2014-2017. Merck, S.L.U. Proyecto de colaboración entre Merck y IIER-ISCIII. TVP 1316/13.
- “Caracterización genética y funcional de la histiocitosis pulmonar de células de Langerhans: implicaciones diagnósticas y terapéuticas”. 2013-2016. SEPAR EPID-Futuro (04-2013).
- “Caracterización genética y funcional de la histiocitosis pulmonar de células de Langerhans: implicaciones diagnósticas y terapéuticas”. 2013-2015. Fundación Mutua Madrileña.
Publicaciones destacadas
Survival Patterns of Human Prion Diseases in Spain, 1998-2018: Clinical Phenotypes and Etiological Clues
Tejedor-Romero L, López-Cuadrado T, Almazán-Isla J, Calero M, García López FJ, de Pedro-Cuesta J. Survival Patterns of Human Prion Diseases in Spain, 1998-2018: Clinical Phenotypes and Etiological Clues. Front Neurosci. 2022 15:773727. doi: 10.3389/fnins.2021.773727. eCollection 2021.
DOIATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization
Tazelaar GHP, Boeynaems S, De Decker M, van Vugt J, Kool L, Goedee HS, et al. ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization. Brain Commun. 2020,2(2):fcaa064. Q1
Magnetic microbeads-based amperometric immunoplatform for the rapid and sensitive detection of N6-methyladenosine to assist in metastatic cancer cells discrimination
Eloy Povedano, María Gamella, Rebeca M. Torrente-Rodríguez, Ana Montero-Calle, María Pedrero, Guillermo Solís-Fernández, Fernando Navarro-Villoslada, Rodrigo Barderas, Susana Campuzano, José M. Pingarrón. Magnetic microbeads-based amperometric immunoplatform for the rapid and sensitive detection of N6-methyladenosine to assist in metastatic cancer cells discrimination. Biosensors and Bioelectronics. 2021; 171:112708
DOISOS GEFs in health and disease
Baltanás FC, Zarich N, Rojas- Cabañeros JM & Santos E. SOS GEFs in health and disease. BBA-Reviews on Cancer. 2020; 188445. doi: 10.1016/j.bbcan.2020.188445
DOIThyroid hormone increases bulk histones expression by enhancing translational efficiency
Thyroid hormone increases bulk histones expression by enhancing translational efficiency. Zambrano A, García-Carpizo V, Villamuera R, Aranda A. Mol Endocrinol. 2015 Jan;29(1):68-75. doi: 10.1210/me.2014-1235. PMID: 25422881; PMCID: PMC5414774.
PUBMED DOIEpidemiological bases and molecular mechanisms linking obesity, diabetes, and cancer
Gutiérrez-Salmerón M, Chocarro-Calvo A, García-Martínez JM, de la Vieja A, García-Jiménez C. Epidemiological bases and molecular mechanisms linking obesity, diabetes, and cancer. Endocrinol Diabetes Nutr. 2017 Feb; 64(2):109-117. (https://www.ncbi.nlm.nih.gov/pubmed/28440775) doi:10.1016/j.endinu.2016.10.005
PUBMED DOISalivary lactoferrin as biomarker for Alzheimer's disease: Brain-immunity interactions
Bermejo-Pareja F, Del Ser T, Valentí M, de la Fuente M, Bartolome F, Carro E. Salivary lactoferrin as biomarker for Alzheimer's disease: Brain-immunity interactions. Alzheimers Dement. 2020 Aug;16(8):1196-1204. doi: 10.1002/alz.12107.
DOIOcoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma
Hernández SanMiguel, E.; Gargini, R.; Cejalvo, T., Segura-Collar B, Núñez-Hervada P, Hortigüela R, Sepúlveda-Sánchez JM, Hernández-Laín A, Pérez-Núñez A, Sanz E, Sánchez Gómez, P. (2019) Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma. Oxid.Med.Cell. Longev. pp.9719730. PMID: 31467641. doi: 10.1155/2019/9719730
DOIImpact of environmental neurotoxic: current methods and usefulness of human stem cells
Rosca, A.; Coronel, R.; Moreno, M.; González, R.; Oniga, A.; Martín, A.; López, V.; González, M.C.; Liste, I. (2020). Impact of environmental neurotoxic: current methods and usefulness of human stem cells. Heliyon. 6, e05773. doi: 10.1016/j.heliyon.2020.e05773.
DOIGenomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
de Rojas I, Hernández I, Montrreal L, Quintela I, Calero M, Royo JL, Huerto Vilas R, González-Pérez A, Franco-Macías E, Macías J, Menéndez-González M, Frank-García A, Diez-Fairen M, Lage C, García-Madrona S, Aguilera N, García-González P, Puerta R, Sotolongo-Grau O, Alonso-Lana S, Rábano A, Arias Pastor A, Pastor AB, Corma-Gómez A, Martín Montes A, Martínez Rodríguez C, Buiza-Rueda D, Periñán MT, Rodriguez-Rodriguez E, Alvarez I, Rosas Allende I, Pineda JA, Bernal Sánchez-Arjona M, Fernández-Fuertes M, Mendoza S, Del Ser T, Gr Ace/Degesco Consortium, Garcia-Ribas G, Sánchez-Juan P, Pastor P, Bullido MJ, Álvarez V, Real LM, Mir P, Piñol-Ripoll G, García-Alberca JM, Medina M, Orellana A, Butler CR, Marquié M, Sáez ME, Carracedo Á, Tárraga L, Boada M, Ruiz A. Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study. J Pers Med. 2021 11(12):1318. doi: 10.3390/jpm11121318.
DOIImpact of environmental neurotoxic: current methods and usefulness of human stem cells
Rosca A, Coronel R, Moreno M, Gonzalez R, Oniga A, Martin A, et al. Impact of environmental neurotoxic: current methods and usefulness of human stem cells. Heliyon. 2020,6(12):e05773. Q1
Bringing to Light the Importance of the miRNA Methylome in Colorectal Cancer Prognosis Through Electrochemical Bioplatforms
Povedano E, Ruiz-Valdepeñas Montiel V, Sebuyoya R, Torrente-Rodríguez RM, Garranzo-Asensio M, Montero-Calle A, Pingarrón JM, Barderas R, Bartosik M, Campuzano S. Bringing to Light the Importance of the miRNA Methylome in Colorectal Cancer Prognosis Through Electrochemical Bioplatforms. Analytical Chemistry 2024;96:4580
DOIMinilungs from Human Embryonic Stem Cells to Study the Interaction of Streptococcus pneumoniae with the Respiratory Tract
Sempere J, Rossi SA, Chamorro-Herrero I, González-Camacho F, de Lucas MP, Rojas-Cabañeros JM, Taborda CP, Zaragoza O, Yuste J & Zambrano A. Minilungs from Human Embryonic Stem Cells to Study the Interaction of Streptococcus pneumoniae with the Respiratory Tract. Microbiology Spectrum. 2022; 10(3):e00453-22. doi: 10.1128/spectrum.00453-22
DOIThe thyroid hormone receptor β induces DNA damage and premature senescence
The thyroid hormone receptor β induces DNA damage and premature senescence. Zambrano A, García-Carpizo V, Gallardo ME, Villamuera R, Gómez-Ferrería MA, Pascual A, Buisine N, Sachs LM, Garesse R, Aranda A. J Cell Biol. 2014 Jan 6;204(1):129-46. doi: 10.1083/jcb.201305084. PMID: 24395638; PMCID: PMC3882795.
PUBMED DOIFrom obesity to diabetes and cancer: epidemiological links and role of therapies
García-Jiménez C, Gutiérrez-Salmerón M, Chocarro-Calvo A, García-Martínez JM, Castaño A, De la Vieja A. From obesity to diabetes and cancer: epidemiological links and role of therapies. Br J Cancer. 2016 Mar 29; 114(7):716-22. (https://www.ncbi.nlm.nih.gov/pubmed/26908326) doi: 10.1038/bjc.2016.37
PUBMED DOIAquaporin 5 in Alzheimer's disease: a link between oral and brain pathology?
Municio C, Carro E. Aquaporin 5 in Alzheimer's disease: a link between oral and brain pathology? Neural Regen Res. 2023 Jul;18(7):1491-1492. doi: 10.4103/1673-5374.361545.
DOIThe Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration
Villanueva AA, Falcón P, Espinoza N, R LS, Milla LA, Hernández-SanMiguel E, Torres VA, Sanchez-Gomez P, Palma V. (2017) The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration. Oncotarget 8(6):9767-9782. PMID: 28038459 doi: 18632/oncotarget.14213
DOIAnalysis of Benzalkonium Chloride Resistance and Potential Virulence of Listeria monocytogenes Isolates Obtained from Different Stages of a Poultry Production Chain in Spain
Lopez-Alonso V, Ortiz S, Corujo A, Martinez-Suarez JV. Analysis of Benzalkonium Chloride Resistance and Potential Virulence of Listeria monocytogenes Isolates Obtained from Different Stages of a Poultry Production Chain in Spain. J Food Prot. 2020,83(3):443-51. Q2
Physiological and pathological effects of amyloid-β species in neural stem cell biology
Bernabeu-Zornoza, A.; Coronel, R.; Palmer, C.; Monteagudo, M.; Zambrano, A.; Liste, I. (2019). Physiological and pathological effects of amyloid-β species in neural stem cell biology. Neural Regen Res. 14, 2035-2042. doi: 10.4103/1673-5374.262571.
DOInull
Leoni SG, Sastre-Perona A, De la Vieja A*, Santisteban P*. Selenium Increases Thyroid-Stimulating Hormone-Induced Sodium/Iodide Symporter Expression Through Thioredoxin/Apurinic/Apyrimidinic Endonuclease 1-Dependent Regulation of Paired Box 8 Binding Activity. Antioxid Redox Signal. 2016 May 20; 24(15):855-66. (*co-corresponding authors) (IF: 6,337)
PUBMED DOI