We protect your health through science
Investigación
Endotelio Funcional
Líneas de investigación
Content with Investigacion .
Endotelio Funcional
Nuestro objetivo principal es estudiar la funcionalidad del sistema endotelial como herramienta diagnóstica y terapéutica en diferentes patologías humanas principalmente del sistema respiratorio.
Líneas de investigación. (1) Contribución del sistema vascular a enfermedades pulmonares mediadas por trastornos inflamatorios o focos de fibrosis. (2) Evaluación y regulación de la transición endotelio-mesénquima e implicación patológica. (3) Efecto de la contaminación ambiental sobre la fisiología pulmonar. (4) Reprogramación endotelial hacia iPS. (5) Papel de las células endoteliales en regeneración tisular.
Proyectos de investigación
Content with Investigacion .
Proyectos como Investigador Principal.
- “Mecanismos endoteliales implicados en la protección, reparación y regeneración tisular tras alteraciones inflamatorias o fibrosis en enfermedades respiratorias raras”. 2019-2023. FIS, PI18CIII/00040 (IERPY-M 389/18).
- “Contribución del endotelio vascular a la patología inflamatoria y fibrótica en las enfermedades pulmonares raras”. 2016-2018. FIS, PI15CIII/00044 (IERPY 1149/16).
- “Regulation of the polarization of tumor associated macrophages by the ARF gene and its functionality on tumor angiogenesis”. 2013-2016. Instituto Salud Carlos III. TPY-M 1068/13.
Proyectos como Investigador Colaborador.
- “Estudio de la contribución de la microbiota, el metabolismo y la inmunidad innata a la aparición y progresión de las enfermedades pulmonares intersticiales”. 2023-2024. AESI IERPY-M 308/20 (PI20CIII/00018).
- “Impulso de investigación del sistema inmune en la resistencia de las terapias antitumorales”. 2014-2017. Merck, S.L.U. Proyecto de colaboración entre Merck y IIER-ISCIII. TVP 1316/13.
- “Caracterización genética y funcional de la histiocitosis pulmonar de células de Langerhans: implicaciones diagnósticas y terapéuticas”. 2013-2016. SEPAR EPID-Futuro (04-2013).
- “Caracterización genética y funcional de la histiocitosis pulmonar de células de Langerhans: implicaciones diagnósticas y terapéuticas”. 2013-2015. Fundación Mutua Madrileña.
Publicaciones destacadas
Unraveling autoimmune and neurodegenerative diseases by amperometric serological detection of antibodies against aquaporin-4
Arévalo B, Blázquez M, Serafín V, Montero-Calle A, Calero M, Valverde A, Barderas R, Campuzano S, Yáñez-Sedeño P, Pingarrón JM. Unraveling autoimmune and neurodegenerative diseases by amperometric serological detection of antibodies against aquaporin-4. Bioelectrochemistry. 2021 144:108041. doi: 10.1016/j.bioelechem.2021.108041.
DOISpatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis
Solís-Fernández G, Montero-Calle A, Martínez-Useros J, López-Janeiro Á, de los Ríos V, Sanz R, Dziakova J, Milagrosa E, Fernández-Aceñero MJ, Peláez-García A, et al. Spatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis. Cells. 2022; 11(3):447
DOIPKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability
Martínez N, Gragera T, de Lucas MP, Cámara AB, Ballester A, Anta B, Fernández-Medarde A, López-Briones T, Ortega J, Peña-Jiménez D, Barbáchano A, Montero-Calle A, Cordero V, Barderas R, Iglesias T, Yunta M, Oliva JL, Muñoz A, Santos E, Zarich N & Rojas-Cabañeros JM. PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability. Oncogenesis. 2023; 12:20. doi.org/10.1038/s41389-023-00465-3
DOIDecreased salivary lactoferrin levels are specific to Alzheimer's disease
González-Sánchez M, Bartolome F, Antequera D, Puertas-Martín V, González P, Gómez-Grande A, Llamas-Velasco S, Herrero-San Martín A, Pérez-Martínez D, Villarejo-Galende A, Atienza M, Palomar-Bonet M, Cantero JL, Perry G, Orive G, Ibañez B, Bueno H, Fuster V, Carro E. Decreased salivary lactoferrin levels are specific to Alzheimer's disease. EBioMedicine. 2020 Jul;57:102834. doi: 10.1016/j.ebiom.2020.102834.
DOIApplied mathematics and nonlinear sciences in the war on cancer
Pérez-García VM, Fitzpatrick S, Pérez-Romasanta LA, Pesic M, Schucht P, Arana E, Sánchez-Gómez P. (2016) Applied mathematics and nonlinear sciences in the war on cancer. App. Math. Nonlin. Sci. 1(2): 423–436 doi: 10.21042/AMNS.2016.2.00036
DOIPhysiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved
Coronel, R.; Palmer, C.; Bernabeu-Zornoza, A.; Monteagudo, M.; Rosca, A.; Zambrano, A.; Liste, I. (2019). Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved. Neural Regen Res. 14, 1661-1671. doi: 10.4103/1673-5374.257511.
DOIInsulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin
García-Martínez JM, Chocarro-Calvo A, De la Vieja A, García-Jiménez C. Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin. Biochim Biophys Acta. 2014 Nov; 1839(11):1141-50. (https://www.ncbi.nlm.nih.gov/pubmed/25091498) doi:10.1016/j.bbagrm.2014.07.020
PUBMED DOIImpaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance
Lopez-Vilaret KM, Cantero JL, Fernandez-Alvarez M, Calero M, Calero O, Lindín M, Zurrón M, Díaz F, Atienza M. Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance. Aging (Albany NY). 2021 13(21):23936-23952. doi: 10.18632/aging.203668.
DOIThe project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public
van der Spek RAA, van Rheenen W, Pulit SL, Kenna KP, van den Berg LH, Veldink JH, et al. The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public. Amyotroph Lateral Scler Frontotemporal Degener. 2019,20(5-6):432-40. Q1
Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis
Torres Iglesias G, Fernández-Fournier M, Botella L, Piniella D, Laso-García F, Gómez-de Frutos MC, Chamorro B, Puertas I, Tallón Barranco A, Fuentes B, de Leciñana MA, Alonso-López E, Bravo SB, Miranda-Carús ME, Montero-Calle A, Barderas R, Díez-Tejedor E, Gutiérrez-Fernández M, Otero-Ortega L. Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis. Brain, Behavior, and Immunity. 2023; 113:44
DOISalivary lactoferrin is associated with cortical amyloid-beta load, cortical integrity, and memory in aging
Reseco L, Atienza M, Fernandez-Alvarez M, Carro E, Cantero JL. Salivary lactoferrin is associated with cortical amyloid-beta load, cortical integrity, and memory in aging. Alzheimers Res Ther. 2021 Sep 6;13(1):150. doi: 10.1186/s13195-021-00891-8.
DOIPreclinical test of dacomitinib, an irreversible EGFR inhibitor, confirms its effectiveness for glioblastoma
Zahonero C, Aguilera P, Ramírez-Castillejo C, Pajares M, Bolós MV, Cantero C, Pérez-Núñez A, Hernández-Laín A, Sánchez-Gómez P*, Sepúlveda JM*. (*Co-corresponding authors) (2015) Preclinical test of dacomitinib, an irreversible EGFR inhibitor, confirms its effectiveness for glioblastoma. Mol. Can. Ther. 14(7):1548-58. PMID: 25939761 doi: 10.1158/1535-7163.MCT-14-0736
DOIWhole-Genome Sequences of Seven Listeria monocytogenes Strains from Different Stages of a Poultry Meat Production Chain
Lopez-Alonso V, Ortiz S, Martinez-Suarez JV. Whole-Genome Sequences of Seven Listeria monocytogenes Strains from Different Stages of a Poultry Meat Production Chain. Microbiol Resour Announc. 2019,8(11). Q4
Role of amyloid precursor protein (APP) and its derivatives in the biology and cell fate specification of neural stem cells
Coronel, R.; Bernabeu-Zornoza, A.; Palmer, C.; Muñiz-Moreno, M.; Zambrano, A.; Cano, E.; Liste, I. (2018). Role of amyloid precursor protein (APP) and its derivatives in the biology and cell fate specification of neural stem cells. Mol Neurobiol. 55, 7107-7117. doi: 10.1007/s12035-018-0914-2.
DOIMedial Temporal Lobe Involvement in Human Prion Diseases: Implications for the Study of Focal Non Prion Neurodegenerative Pathology
Rábano A, Guerrero Márquez C, Juste RA, Geijo MV, Calero M. Medial Temporal Lobe Involvement in Human Prion Diseases: Implications for the Study of Focal Non Prion Neurodegenerative Pathology. Biomolecules. 2021 Mar 10;11(3):413. doi: 10.3390/biom11030413.
DOIFlat clathrin lattices are linked to metastatic potential in colorectal cancer
Cresens C, Solís-Fernández G, Tiwari A, Nuyts R, Hofkens J, Barderas R, Rocha S. Flat clathrin lattices are linked to metastatic potential in colorectal cancer. iScience. 2023; 26: 107327
DOINIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer
Riesco-Eizaguirre G, Leoni SG, Mendiola M, Estévez-Cebrero MA, Gallego MI, Redondo A, Hardisson D, Santisteban P, De la Vieja A. NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer. J Clin Endocrinol Metab. 2014 Jul; 99(7):E1199-208. (https://www.ncbi.nlm.nih.gov/pubmed/24708099) doi: 10.1210/jc.2013-4249
PUBMED DOIStandardizing salivary lactoferrin measurements to obtain a robust diagnostic biomarker for Alzheimer's disease
Bartolome F, Orive G, Carro E. Standardizing salivary lactoferrin measurements to obtain a robust diagnostic biomarker for Alzheimer's disease. Alzheimers Dement (Amst). 2021 May 2;13(1):e12173. doi: 10.1002/dad2.12173.
DOIControlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma
González-Gómez P, Crecente-Campo J, Zahonero C, de la Fuente M, Hernández-Laín A, Mira H*, Sánchez-Gómez P*, García-Fuentes M* (* Co-corresponding authors). (2015) Controlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma. Oncotarget, 6 (13): 10950-10963. PMID: 25860932 doi: 10.18632/oncotarget.3459
DOIAdvances in Alzheimer’s disease research: Human cerebral organoids
Mateos-Martínez, P.; González-Sastre, R.; Coronel, R.; Rosca, A.; Martín-Benito, S.; Bernabeu-Zornoza, A.; López-Alonso, V.; Liste, I. (2023). Advances in Alzheimer’s disease research: Human cerebral organoids. Am J Biomed Sci & Res. 18, AJBSR.MS.ID.002421. doi: 10.34297/AJBSR.2023.18.002421.
DOI