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Neuro-Oncología
Publicaciones destacadas
NKG2C/KLRC2 tumor cell expression enhances immunotherapeutic efficacy against glioblastoma
de Dios O, Ramírez-González MA, Gómez-Soria I, Segura-Collar B, de Andrea CE, Fernández-Rubio L, Hernández-Laín A, Sepúlveda-Sánchez JM, Jiménez-Roldán L, García-Posadas G, Rodríguez-Ruiz ME, Pérez-Núñez A, Wainwright D.A., Gargini R*, Sánchez-Gómez P*. (2024) NKG2C/KLRC2 tumor cell expression enhances immunotherapeutic efficacy against glioblastoma. J. Immunother. Cancer (in press). (IF: 10.3) (D1) (Immunology / Oncology)1. de Dios O, Ramírez-González MA, Gómez-Soria I, Segura-Collar B, de Andrea CE, Fernández-Rubio L, Hernández-Laín A, Sepúlveda-Sánchez JM, Jiménez-Roldán L, García-Posadas G, Rodríguez-Ruiz ME, Pérez-Núñez A, Wainwright D.A., Gargini R*, Sánchez-Gómez P*. (2024). J. Immunother. Cancer (in press). (IF: 10.3) (D1) (Immunology / Oncology)
Isolation and characterization of milk exosomes for use in advanced therapies
Medel-Martínez A, Redrado-Osta A, Crespo-Barreda A, Sancho-Albero M, Sánchez-Paniagua L, Sebastián V, Pardo M, De la Vieja A, and Martín-Duque P. Isolation and characterization of milk exosomes for use in advanced therapies. Biomolecules 2024
Micromotor-based electrochemical immunoassays for reliable determination of amyloid-β (1-42) in Alzheimer's diagnosed clinical samples
Gordón Pidal JM, Moreno-Guzmán M, Montero-Calle A, Valverde A, Pingarrón JM, Campuzano S, Calero M, Barderas R, López MÁ, Escarpa A. Micromotor-based electrochemical immunoassays for reliable determination of amyloid-β (1-42) in Alzheimer's diagnosed clinical samples. Biosens Bioelectron. 2024 249:115988. doi: 10.1016/j.bios.2023.115988.
DOIHuman cerebral organoids: Cellular composition and subcellular morphological features
Mateos-Martínez, P., Coronel, R., Sachse, M., González-Sastre, R., Maeso, L., Rodriguez, M.J., Terrón, M.C., López-Alonso, V., Liste, I. (2024). Human cerebral organoids: Cellular composition and subcellular morphological features. Front Cell Neurosci. 18. doi: 10.3389/fncel.2024.1406839.
DOIPKD phosphorylation and COP9/Signalosome modulate intracelular Spry2 protein stability
Martínez N, Gragera T, de Lucas MP, Cámara AB, Ballester A, Anta B, Fernández-Medarde A, López-Briones T, Ortega J, Peña-Jiénez D, Barbáchano A, Montero-Calle A, Cordero V, Barderas R, Iglesias T, Yunta M, Oliva JL, Muñoz A, Santos E, Zarich N and Rojas JM. PKD phosphorylation and COP9/Signalosome modulate intracelular Spry2 protein stability. Oncogenesis (2023) 12:20. DOI:10.1038/s41389-023-00465-3
DOIOlfactory Receptor OR2K2 Expression in Human Choroid Plexus as a Potential Marker in Early Sporadic Alzheimer's Disease
Alves VC, Figueiro-Silva J, Trullas R, Ferrer I, Carro E. Olfactory Receptor OR2K2 Expression in Human Choroid Plexus as a Potential Marker in Early Sporadic Alzheimer's Disease. Genes (Basel). 2024 Mar 21;15(3):385. doi: 10.3390/genes15030385.
DOIStructural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis
Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis. Al Khleifat A, Iacoangeli A, van Vugt JJFA, Bowles H, Moisse M, Zwamborn RAJ, van der Spek RAA, Shatunov A, Cooper-Knock J, Topp S, Byrne R, Gellera C, López V, Jones AR, Opie-Martin S, Vural A, Campos Y, van Rheenen W, Kenna B, Van Eijk KR, Kenna K, Weber M, Smith B, Fogh I, Silani V, Morrison KE, Dobson R, van Es MA, McLaughlin RL, Vourc'h P, Chio A, Corcia P, de Carvalho M, Gotkine M, Panades MP, Mora JS, Shaw PJ, Landers JE, Glass JD, Shaw CE, Basak N, Hardiman O, Robberecht W, Van Damme P, van den Berg LH, Veldink JH, Al-Chalabi A. NPJ Genom Med. 2022;7(1):8. DOI: 10.1038/s41525-021-00267-9
DOIHuman cerebral organoids: Cellular composition and subcellular morphological features.
Mateos-Martínez, P., Coronel, R., Sachse, M., González-Sastre, R., Maeso, L., Rodriguez, M.J., Terron, M.C., López Alonso, V.*, Liste I. (2024). Human cerebral organoids: Cellular composition and subcellular morphological features. Front Cell Neurosci. Publicado (12.06.2024). IF = 5.3; Q1.
Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis
Solís-Fernández G, Montero-Calle A, Sánchez-Martínez M, Pelaez-Garcia A, Fernandez-Aceñero MJ, Pallares P, Mendiola M, Hendrix J, Hardissom D, Bartolome RA, Hofkens J, Rocha S, Barderas R. Aryl-hydrocarbon receptor-interacting protein regulates tumorigenic and metastatic properties of colorectal cancer cells driving liver metastasis. Br J Cancer 126, 1604–1615 (2022)
DOIVisualization of Lipid Droplets in the Alveolar Macrophage Cell Line MH-S with Live-cell Imaging by 3D Holotomographic Microscopy (Nanolive)
Pérez-Montero A, Zaragoza O, Luque A, Hortelano S, Acebo P. Visualization of Lipid Droplets in the Alveolar Macrophage Cell Line MH-S with Live-cell Imaging by 3D Holotomographic Microscopy (Nanolive). Bio Protoc. 2023 Mar 5;13(5):e4629. doi: 10.21769/BioProtoc.4629.
DOIModeling of Respiratory Diseases Evolving with Fibrosis from Organoids Derived from Human Pluripotent Stem Cells
Modeling of Respiratory Diseases Evolving with Fibrosis from Organoids Derived from Human Pluripotent Stem Cells. Chamorro-Herrero I, Zambrano A. Int J Mol Sci. 2023 Feb 23;24(5):4413. doi: 10.3390/ijms24054413. PMID: 36901843; PMCID: PMC10002124.
PUBMED DOIEndothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells
Ibiza S, Pérez-Rodríguez A, Ortega A, Martínez-Ruiz A, Barreiro O, García-Domínguez CA, Víctor VM, Esplugues JV, Rojas JM, Sánchez-Madrid F & Serrador JM. Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells. Proceedings of the National Academy of Sciences USA. 2008; 105: 10507- 12. doi:10.1073/pnas.0711062105
DOIAge-stratified comorbid and pharmacologic analysis of patients with glioblastoma
Rabin EE, Huang J, Kim M, Mozny A, Lauing KL, Penco-Campillo M, Zhai L, Bommi P, Mi X, Power EA, Prabhu VC, Anderson DE, Barton KP, Walunas TL, Schiltz GE, Amidei C, Sanchez-Gomez P, Thakkar JP, Lukas RV, Wainwright DA. (2024) Age-stratified comorbid and pharmacologic analysis of patients with glioblastoma. Brain Behav. Immun. Health Mar 15:38:100753. PMID: 38600951 doi: 10.1016/j.bbih.2024.100753
DOIPromising anticancer prodrugs based on Pt(IV) complexes with bis-organosilane ligands in axial positions
Navas F, Chocarro-Calvo A, Iglesias-Hernández P, Fernández-García P, Morales V, García-Martínez JM, Sanz R, De la Vieja A*, García Jiménez C* and García Muñoz R*. Promising anticancer prodrugs based on Pt(IV) complexes with bis-organosilane ligands in axial positions. Journal of Medicinal Chemistry. 2024. DOI: 10.1021/acs.jmedchem.3c02393. PMID: 38592014
PUBMED DOIIn Vivo Ultrafast Doppler Imaging Combined with Confocal Microscopy and Behavioral Approaches to Gain Insight into the Central Expression of Peripheral Neuropathy in Trembler-J Mice
Martínez Barreiro M, Vázquez Alberdi L, De León L, Avellanal G, Duarte A, Anzibar Fialho M, Baranger J, Calero M, Rubido N, Tanter M, Negreira C, Brum J, Damián JP, Kun A. In Vivo Ultrafast Doppler Imaging Combined with Confocal Microscopy and Behavioral Approaches to Gain Insight into the Central Expression of Peripheral Neuropathy in Trembler-J Mice. Biology (Basel). 2023 12(10):1324. doi: 10.3390/biology12101324.
DOIBackground levels and brain organoid impact of RF field exposure in a healthcare environment
Hernández, J.A.; Rosca, A.; Suárez, S.; Coronel, R.; Suarez, O.J.; Peran-Ramos, P.; Marina, P.; Rabassa, L.E.; Mateos, P.; Liste, I.; López-Alonso, V.; Torres-Ruiz, M.; Febles, V.M.; Ramos V. (2024). Background levels and brain organoid impact of RF field exposure in a healthcare environment. Front Antennas Propag. 2, 1357649. IF = In progress (New Journal).
Effects of nanomolar methylmercury on developing human neural stem cells and zebrafish embryo
Torres-Ruiz, M.; de Alba-Gonzalez, M.; Cañas-Portilla, A.I.; Coronel, R.; Liste, I.; González-Caballero, M.C. (2024). Effects of nanomolar methylmercury on developing human neural stem cells and zebrafish embryo. Food Chem Toxicol. 188, 114684. doi: 10.1016/j.fct.2024.114684
DOIHedgehog signalling modulates immune response and protecs againts Experimental Autoimmune Encephalomyelitis
Ballester A, Guijarro A, Bravo B, Hernández J, Murillas R, Gallego MI and Ballester S. 2022. Hedgehog signalling modulates immune response and protecs againts Experimental Autoimmune Encephalomyelitis. International Journal of Molecular Sciences (2022) 23, 3171. DOI: 10.3390/ijms23063171
DOICircadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
Carrero L, Antequera D, Municio C, Carro E. Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease? Neural Regen Res. 2024 Sep 1;19(9):1967-1972. doi: 10.4103/1673-5374.390962.
DOITelomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data
Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data. Al Khleifat A, Iacoangeli A, Jones AR, van Vugt JJFA, Moisse M, Shatunov A, Zwamborn RAJ, van der Spek RAA, Cooper-Knock J, Topp S, van Rheenen W, Kenna B, Van Eijk KR, Kenna K, Byrne R, López V, Opie-Martin S, Vural A, Campos Y, Weber M, Smith B, Fogh I, Silani V, Morrison KE, Dobson R, van Es MA, McLaughlin RL, Vourc'h P, Chio A, Corcia P, de Carvalho M, Gotkine M, Panades MP, Mora JS, Shaw PJ, Landers JE, Glass JD, Shaw CE, Basak N, Hardiman O, Robberecht W, Van Damme P, van den Berg LH, Veldink JH, Al-Chalabi A. Front Cell Neurosci. 2022; 16:1050596.
DOIInformación adicional
El trabajo de nuestra Unidad se centra en el estudio del comportamiento de los tumores cerebrales, en concreto los gliomas de grado 4, los glioblastomas (GBM), que son tumores muy agresivos y con un índice de supervivencia de unos 12-15 meses. Entre las principales barreras en el tratamiento de estos tumores están su elevada heterogeneidad y su alto nivel de quimioresistencia a los agentes citotóxicos convencionales A pesar de que la cirugía elimine la masa tumoral principal y el paciente sea tratado con radioterapia local y quimioterapia sistémica, los GBM siempre recidivan a partir de las células tumorales que quedan en el cerebro tras la cirugía, siendo responsables de la muerte del paciente. En el laboratorio seguimos un abordaje traslacional para caracterizar la distribución de las células tumorales tanto en el centro del tumor como en las zonas periféricas, así como su interacción con las células del microambiente cerebral, que también participan en la agresividad de estos tumores.
La Unidad colabora estrechamente con expertos clínicos del Hospital 12 de Octubre, lo que nos permite participar en estudios moleculares y celulares con muestras de pacientes (ver como ejemplo la figura de abajo), así como establecer cultivos primarios y alo- y xeno-injertos en modelos murinos. Estos modelos son utilizados en diferentes proyectos de investigación en colaboración con empresas farmacéuticas y con otros equipos de investigación multidisciplinares (matemáticos, ingenieros, bioinformáticos, químicos). Nuestro objetivo final es mejorar las terapias existentes, o bien diseñar estrategias alternativas.
Link a la página web del laboratorio: http://www.gliomalab.com
Redes:
@gliomalab
https://www.linkedin.com/in/pilar-s%C3%A1nchez-g%C3%B3mez-7b571826