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Neuro-Oncología
Publicaciones destacadas
Efficient generation of human cerebral organoids directly from adherent cultures of pluripotent stem cells
González-Sastre, R.; Coronel, R.; Bernabeu-Zornoza, A.; Mateos-Martínez, P.; Rosca, A.; López-Alonso, V.; Liste, I. (2024). Efficient generation of human cerebral organoids directly from adherent cultures of pluripotent stem cells. J Tissue Eng. 15, 20417314231226027. doi: 10.1177/20417314231226027
DOIEditorial: IL-2/IL-2R axis modulation by mesenchymal stromal cells: interaction with immunosuppressive drugs?
Ballester S and Ballester A. Editorial: IL-2/IL-2R axis modulation by mesenchymal stromal cells: interaction with immunosuppressive drugs? Journal of Leukocyte Biology (2017) 101-3, pp.617-619. ISSN 1938-3673, (editorial by invitation) doi:10.1189/jlb.5CE0916-393R
PUBMED DOISaliva is a Good Candidate to be the New Gold-Standard Sample for Neurodegenerative Diseases
Orive G, Lopera F, Carro E. Saliva is a Good Candidate to be the New Gold-Standard Sample for Neurodegenerative Diseases. J Alzheimers Dis. 2022;87(4):1497-1501. doi: 10.3233/JAD-220144.
DOIChoroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer's Disease
Municio C, Carrero L, Antequera D, Carro E. Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer's Disease. Int J Mol Sci. 2023 Jan 3;24(1):878. doi: 10.3390/ijms24010878.
DOIEuropean mitochondrial haplogroups are associated with CD4+ T cell recovery in HIV-infected patients on combination antiretroviral therapy
European mitochondrial haplogroups are associated with CD4+ T cell recovery in HIV-infected patients on combination antiretroviral therapy. María Guzmán Fulgencio; Juan Berenguer; Dariela Micheloud; Amanda Fernández Rodríguez; Mónica García Álvarez; María Angeles Jiménez Sousa; José María Bellón; Yolanda Campos; Jaime Cosín; Teresa Aldámiz Echevarría; Pilar Catalán; Juan Carlos López; Salvador Resino. The Journal of antimicrobial chemotherapy. 2013; 68: 2349 - 2406. DOI: 10.1093/jac/dkt206
DOIMultiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer
Ana Montero-Calle, Itziar Aranguren-Abeigon, María Garranzo-Asensio, Carmen Poves, María Jesús Fernández-Aceñero, Javier Martínez-Useros, Rodrigo Sanz, Jana Dziaková, Javier Rodriguez-Cobos, Guillermo Solís-Fernández, Eloy Povedano, Maria Gamella, Rebeca Magnolia Torrente-Rodríguez, Miren Alonso-Navarro, Vivian de los Ríos, J. Ignacio Casal, Gemma Domínguez, Ana Guzman-Aranguez, Alberto Peláez-García, José Manuel Pingarrón, Susana Campuzano, Rodrigo Barderas. Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer. Engineering 2021; 7:1393.
DOIA hispanolone-derived diterpenoid inhibits M2-Macrophage polarization in vitro via JAK/STAT and attenuates chitin induced inflammation in vivo
Jiménez-García L; Higueras MA; Herranz S; Hernández-López M; Luque A; de las Heras B; Hortelano S. 2018. A hispanolone-derived diterpenoid inhibits M2-Macrophage polarization in vitro via JAK/STAT and attenuates chitin induced inflammation in vivo. Biochem Pharmacol. 2018 Aug;154:373-383. https://doi.org/10.1016/j.bcp.2018.06.002.
DOIIdentification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids
Identification of AAV serotypes for lung gene therapy in human embryonic stem cell-derived lung organoids. Meyer-Berg H, Zhou Yang L, Pilar de Lucas M, Zambrano A, Hyde SC, Gill DR. Stem Cell Res Ther. 2020 Oct 23;11(1):448. doi: 10.1186/s13287-020-01950-x. PMID: 33097094; PMCID: PMC7582027.
PUBMED DOISPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity
Barbáchano A, Ordóñez-Morán P, García JM, Sánchez A, Pereira F, Larriba MJ, Martínez N, Hernández J, Landolfi S, Bonilla F, Pálmer HG, Rojas JM & Muñoz A. SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity. Oncogene. 2010; 29:4800-13. doi:10.1038/onc.2010.225
DOIIDP-410: a Novel Therapeutic Peptide that Alters N-MYC Stability and Reduces Angiogenesis and Tumor Progression in Glioblastomas
Gargini R, Segura-Collar B, Garranzo-Asensio M, Hortigüela R, Iglesias-Hernández P, Lobato-Alonso D, Moreno-Raja M, Esteban-Martin S, Sepúlveda-Sánchez JM, Nevola L, Sánchez-Gómez P. (2022) IDP-410: a Novel Therapeutic Peptide that Alters N-MYC Stability and Reduces Angiogenesis and Tumor Progression in Glioblastomas. Neurotherapeutics. Jan;19(1):408-420. PMID: 35099769 doi: 10.1007/s13311-021-01176-6
DOIVitamin D induces SIRT1 activation through K610 deacetylation in colon cancer
García-Martínez JM, Chocarro-Calvo A, Gutiérrez-Salmerón M, Martinez-Useros J, Fernandez-Aceñedo MJ, Fiuza MC, Cáceres-Rentero J, De la Vieja A, Barbáchano A, Muñoz A, Larriba MJ, and García-Jiménez C*. Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer. eLife 2023. 12:RP86913. doi: 10.7554/eLife.86913. PMID: 37530744
PUBMED DOIHepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study
Pérez-García F, Vázquez-Morón S, Burgueño-García I, Muñoz-Gómez MJ, Zea-Sevilla MA, Calero M, Martínez I, Rábano A, Resino S. Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study. J Infect Dis. 2023 227(7):873-877. doi: 10.1093/infdis/jiac268.
DOILow Levels of Amyloid Precursor Protein (APP) Promote Neurogenesis and Decrease Gliogenesis in Human Neural Stem Cells
Coronel R, Lopez-Alonso V, Gallego, M., Liste I. Low Levels of Amyloid Precursor Protein (APP) Promote Neurogenesis and Decrease Gliogenesis in Human Neural Stem Cells. Int J Mol Sci. 2023: 24(19):14635. Q1.
Internalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells
González-Caballero, M.C.; de Alba-González, M.; Torres-Ruiz, M.; Iglesias-Hernández, P.; Zapata, V.; Terrón, M.C.; Sachse, M.; Morales, M.; Martin-Folgar, R.; Liste, I.; Cañas-Portilla, A.I. (2024). Internalization and toxicity of polystyrene nanoplastics on inmortalized human neural stem cells. Chemosphere. 355, 141815. doi: 10.1016/j.chemosphere.2024.141815.
DOIRestrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis
Bravo B, Gallego MI, Flores AI; Bornstein R, Puente-Bedia A, Hernández J, de la Torre P, García-Zaragoza E, Pérez-Tavarez R, Grande J, Ballester A and Ballester S. Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis. Stem Cell Research & Therapy (2016) 7, PMCID: PMC4797118 doi:10.1186/s13287-016-0304-5
PUBMED DOIImplication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease
Municio C, Carro E. Implication of salivary lactoferrin and periodontal-mediated infections in Alzheimer's disease. Neural Regen Res. 2023 Dec;18(12):2691-2692. doi: 10.4103/1673-5374.373712.
DOIMitochondrial haplogroups are associated with clinical pattern of AIDS progression in HIV-infected patients. Journal of acquired immune deficiency syndromes• Mitochondrial haplogroups are associated with clinical pattern of AIDS progression in HIV-infected patients. Journal of acquired immune deficiency syndromes
Mitochondrial haplogroups are associated with clinical pattern of AIDS progression in HIV-infected patients. Journal of acquired immune deficiency syndromes. María Guzmán Fulgencio; José Luis Jiménez; Mónica García Álvarez; José María Bellón; Amanda Fernández Rodriguez; Yolanda Campos; Carmen Rodríguez; Juan González Garcia; Melchor Riera; Pompeyo Viciana; Ma Ángeles Muñoz Fernández; Salvador Resino. J Acquir Immune Defic Syndr. 2013 ;63:178-83. DOI: 10.1097/QAI.0b013e3182893f74
DOIIn-depth proteomics characterization of ∆Np73 effectors identifies key proteins with diagnostic potential implicated in lymphangiogenesis, vasculogenesis and metastasis in colorectal cancer
Garranzo-Asensio M, Rodríguez-Cobos J, San Millán C, Poves C, Fernández-Aceñero MJ, Pastor-Morate D, Viñal D, Montero-Calle A, Solís-Fernández G, Ceron MA, Gámez-Chiachio M, Rodríguez N, Guzmán-Aránguez A, Barderas R, Domínguez G. In-depth proteomics characterization of ∆Np73 effectors identifies key proteins with diagnostic potential implicated in lymphangiogenesis, vasculogenesis and metastasis in colorectal cancer. Molecular Oncology 2022; 16: 2672.
DOIScreening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
MA Higueras; L Jiménez-García; S Herranz; S Hortelano; A Luque. 2017. Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response. J Vis Exp. 2017 Sep 15;(127). https://doi.org/10.3791/55824.
DOIPhysiological and pathological effects of amyloid-β species in neural stem cell biology
Physiological and pathological effects of amyloid-β species in neural stem cell biology. Bernabeu-Zornoza A, Coronel R, Palmer C, Monteagudo M, Zambrano A, Liste I. Neural Regen Res. 2019 Dec;14(12):2035-2042. doi: 10.4103/1673-5374.262571. PMID: 31397330; PMCID: PMC6788229.
PUBMED DOIInformación adicional
El trabajo de nuestra Unidad se centra en el estudio del comportamiento de los tumores cerebrales, en concreto los gliomas de grado 4, los glioblastomas (GBM), que son tumores muy agresivos y con un índice de supervivencia de unos 12-15 meses. Entre las principales barreras en el tratamiento de estos tumores están su elevada heterogeneidad y su alto nivel de quimioresistencia a los agentes citotóxicos convencionales A pesar de que la cirugía elimine la masa tumoral principal y el paciente sea tratado con radioterapia local y quimioterapia sistémica, los GBM siempre recidivan a partir de las células tumorales que quedan en el cerebro tras la cirugía, siendo responsables de la muerte del paciente. En el laboratorio seguimos un abordaje traslacional para caracterizar la distribución de las células tumorales tanto en el centro del tumor como en las zonas periféricas, así como su interacción con las células del microambiente cerebral, que también participan en la agresividad de estos tumores.
La Unidad colabora estrechamente con expertos clínicos del Hospital 12 de Octubre, lo que nos permite participar en estudios moleculares y celulares con muestras de pacientes (ver como ejemplo la figura de abajo), así como establecer cultivos primarios y alo- y xeno-injertos en modelos murinos. Estos modelos son utilizados en diferentes proyectos de investigación en colaboración con empresas farmacéuticas y con otros equipos de investigación multidisciplinares (matemáticos, ingenieros, bioinformáticos, químicos). Nuestro objetivo final es mejorar las terapias existentes, o bien diseñar estrategias alternativas.
Link a la página web del laboratorio: http://www.gliomalab.com
Redes:
@gliomalab
https://www.linkedin.com/in/pilar-s%C3%A1nchez-g%C3%B3mez-7b571826