Neurobiología del Alzheimer

Additional mechanisms conferring genetic susceptibility to Alzheimer's disease

Calero M, Gómez-Ramos A, Calero O, Soriano E, Avila J, Medina M. Additional mechanisms conferring genetic susceptibility to Alzheimer's disease. Front Cell Neurosci. 2015 9:138. doi: 10.3389/fncel.2015.00138.

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A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk

Sanchez-Juan P, Bishop MT, Kovacs GG, Calero M, Aulchenko YS, Ladogana A, Boyd A, Lewis V, Ponto C, Calero O, Poleggi A, Carracedo Á, van der Lee SJ, Ströbel T, Rivadeneira F, Hofman A, Haïk S, Combarros O, Berciano J, Uitterlinden AG, Collins SJ, Budka H, Brandel JP, Laplanche JL, Pocchiari M, Zerr I, Knight RS, Will RG, van Duijn CM. A genome wide association study links glutamate receptor pathway to sporadic Creutzfeldt-Jakob disease risk. PLoS One. 2015 10(4):e0123654. doi: 10.1371/journal.pone.0123654.

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Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease

Alcolea D, Martínez-Lage P, Sánchez-Juan P, Olazarán J, Antúnez C, Izagirre A, Ecay-Torres M, Estanga A, Clerigué M, Guisasola MC, Sánchez Ruiz D, Marín Muñoz J, Calero M, Blesa R, Clarimón J, Carmona-Iragui M, Morenas-Rodríguez E, Rodríguez-Rodríguez E, Vázquez Higuera JL, Fortea J, Lleó A. Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease. Neurology. 2015 85(7):626-33. doi: 10.1212/WNL.0000000000001859.

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Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic

Schmitz M, Ebert E, Stoeck K, Karch A, Collins S, Calero M, Sklaviadis T, Laplanche JL, Golanska E, Baldeiras I, Satoh K, Sanchez-Valle R, Ladogana A, Skinningsrud A, Hammarin AL, Mitrova E, Llorens F, Kim YS, Green A, Zerr I. Validation of 14-3-3 Protein as a Marker in Sporadic Creutzfeldt-Jakob Disease Diagnostic. Mol Neurobiol. 2015

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel C82R mutation in the NOTCH3 gene

Zea-Sevilla MA, Bermejo-Velasco P, Serrano-Heranz R, Calero M. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) associated with a novel C82R mutation in the NOTCH3 gene. J Alzheimers Dis. 2015 43(2):363-7. doi: 10.3233/JAD-141218.

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A phase II trial of tideglusib in Alzheimer's disease

Lovestone S, Boada M, Dubois B, Hüll M, Rinne JO, Huppertz HJ, Calero M, Andrés MV, Gómez-Carrillo B, León T, del Ser T; ARGO investigators. A phase II trial of tideglusib in Alzheimer's disease. J Alzheimers Dis. 2015 45(1):75-88. doi: 10.3233/JAD-141959

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A blood-based, 7-metabolite signature for the early diagnosis of Alzheimer's disease

Olazarán J, Gil-de-Gómez L, Rodríguez-Martín A, Valentí-Soler M, Frades-Payo B, Marín-Muñoz J, Antúnez C, Frank-García A, Acedo-Jiménez C, Morlán-Gracia L, Petidier-Torregrossa R, Guisasola MC, Bermejo-Pareja F, Sánchez-Ferro Á, Pérez-Martínez DA, Manzano-Palomo S, Farquhar R, Rábano A, Calero M. A blood-based, 7-metabolite signature for the early diagnosis of Alzheimer's disease. J Alzheimers Dis. 2015 45(4):1157-73. doi: 10.3233/JAD-142925.

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Comparative Incidence of Conformational, Neurodegenerative Disorders

de Pedro-Cuesta J, Rábano A, Martínez-Martín P, Ruiz-Tovar M, Alcalde-Cabero E, Almazán-Isla J, Avellanal F, Calero M. Comparative Incidence of Conformational, Neurodegenerative Disorders. PLoS One. 2015 10(9):e0137342. doi: 10.1371/journal.pone.0137342. eCollection 2015. Erratum in: PLoS One. 2015;10(10):e0140304.

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Investigación