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Neuro-Oncología
Publicaciones destacadas
An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation
Bonfiglio JJ, Leidecker O, Dauben H, Longarini EJ, Colby T, San Segundo-Acosta P, Perez KA, Matic I. An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation. Cell. 2020; 183:1086-1102.e23.
DOIRegulation of endothelial dynamics by PGC-1alpha relies on ROS control of VEGF-A signaling Free Radic Biol Med
I Prieto; C Sánchez-Ramos; A Luque; E Arza; Y Olmos; M Monsalve. (3/6). 2016. Regulation of endothelial dynamics by PGC-1alpha relies on ROS control of VEGF-A signaling Free Radic Biol Med. 2016 Apr;93:41-51. https://doi.org/10.1016/j.freeradbiomed.2016.01.021
DOIEarly induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts
Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts. Prieto I, Zambrano A, Laso J, Aranda A, Samper E, Monsalve M. Free Radic Biol Med. 2019 Jul;138:23-32. doi: 10.1016/j.freeradbiomed.2019.04.015. Epub 2019 Apr 25. PMID: 31029787.
PUBMED DOISos GEFs: old concepts and new perspectives
Rojas JM, Oliva JL & Santos E. Mammalian Sos GEFs: old concepts and new perspectives. Genes & Cancer. 2011; 2: 298-305. doi: 10.1177/1947601911408078
DOIBlood-Brain Barrier Disruption: A Common Driver of Central Nervous System Diseases
Segura-Collar B, Mata-Martínez P, Hernández-Laín A, Sánchez-Gómez P*, Gargini R*. (* co-corresponding) (2021) Blood-Brain Barrier Disruption: A Common Driver of Central Nervous System Diseases. The Neuroscientist. Jan 15: 1073858420985838. PMID: 33446074 doi: 10.1177/1073858420985838
DOIMesenchymal Stem Cells delivery in individuals with different pathologies. Multimodal tracking, safety and future applications
Belmar-López C, Vassaux G, Medel-Martinez A, Burnet J, Quintanilla M, Ramón Y Cajal S, Hernandez-Losa J, De la Vieja A*, and Martin-Duque P*. Mesenchymal Stem Cells delivery in individuals with different pathologies. Multimodal tracking, safety and future applications. International Journal of Molecular Sciences 2022 Jan 31;23(3):1682. doi: 10.3390/ijms23031682. PMID: 35163605
PUBMED DOICurcumin and Ethanol Effects in Trembler-J Schwann Cell Culture
Vázquez Alberdi L, Rosso G, Velóz L, Romeo C, Farias J, Di Tomaso MV, Calero M, Kun A. Curcumin and Ethanol Effects in Trembler-J Schwann Cell Culture. Biomolecules. 2022 12(4):515. doi: 10.3390/biom12040515.
DOITelomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data
Al Khleifat A, Iacoangeli A, Jones AR, van Vugt J, Moisse M, Shatunov A, et al. Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data. Front Cell Neurosci. 2022;16:1050596. Q1.
Amyloid precursor protein (APP) regulates gliogenesis and neurogenesis of human neural stem cells by several signaling pathways
Coronel, R.; Bernabeu-Zornoza, A.; Palmer, C.; González-Sastre, R.; Rosca, A.; Mateos-Martínez, P.; López-Alonso, V.; Liste, I. (2023). Amyloid precursor protein (APP) regulates gliogenesis and neurogenesis of human neural stem cells by several signaling pathways. Int J Mol Sci. 24, 12964. doi: 10.3390/ijms241612964.
DOIIntraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland
García-Zaragoza, E.; Pérez-Tavarez, R.; Ballester, A.; Lafarga, V.; Jiménez- Reinoso, A.; Jiménez-Reinoso, A.; Ramírez, A.; Murillas, R. and Gallego, M.I. Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland. Dev. Biol. (2012) 372-1, pp.28-44. PMID: 23000969 doi:10.1016/j.ydbio.2012.09.005
PUBMED DOIAltered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina
Carrero L, Antequera D, Alcalde I, Megias D, Ordoñez-Gutierrez L, Gutierrez C, Merayo-Lloves J, Wandosell F, Municio C, Carro E. Altered Clock Gene Expression in Female APP/PS1 Mice and Aquaporin-Dependent Amyloid Accumulation in the Retina. Int J Mol Sci. 2023 Oct 27;24(21):15679. doi: 10.3390/ijms242115679.
DOITelomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data
Al Khleifat A, Iacoangeli A, Jones AR, van Vugt J, Moisse M, Shatunov A, et al. Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data. Front Cell Neurosci. 2022;16:1050596. Q1.
Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction
Okur MN, Zhu JO, Fong CW, Martinez N, Garcia-Dominguez C, Rojas JM, Guy G & O'Bryan J. Intersectin 1 enhances Cbl ubiquitylation of epidermal growth factor receptor through regulation of Sprouty2-Cbl interaction. Molecular and Cellular Biology. 2012; 32(4):817-25. doi:10.1128/MCB.05647-11
DOIEuropean mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients
European mitochondrial DNA haplogroups and liver fibrosis in HIV and hepatitis C virus coinfected patients. García-Álvarez M, Guzmán-Fulgencio M, Berenguer J, Micheloud D, Campos Y, López JC, Cosín J, Miralles P, Alvarez E, Resino S. AIDS. 2011;25:1619-926. DOI: 10.1097/QAD.0b013e328349820f
DOIEuropean mitochondrial DNA haplogroups and metabolic disorders in HIV/HCV-coinfected patients on highly active antiretroviral therapy
European mitochondrial DNA haplogroups and metabolic disorders in HIV/HCV-coinfected patients on highly active antiretroviral therapy. Micheloud D, Berenguer J, Guzmán-Fulgencio M, Campos Y, García-Álvarez M, Catalán P, Cosín J, Miralles P, López JC, Resino S.J Acquir Immune Defic Syndr. 2011 ; 58:371-8. DOI: 10.1097/QAI.0b013e31822d2629
DOIMultiplexed monitoring of a novel autoantibody diagnostic signature of colorectal cancer using HaloTag technology-based electrochemical immunosensing platform
Garranzo-Asensio M, Guzmán-Aránguez A, Povedano E, Ruiz-Valdepeñas Montiel V, Poves C, Fernandez-Aceñero MJ, Montero-Calle A, Solís-Fernández G, Fernandez-Diez S, Camps J, Arenas M, Rodríguez-Tomàs E, Joven J, Sanchez-Martinez M, Rodriguez N, Dominguez G, Yáñez-Sedeño P, Pingarrón JM, Campuzano S, Barderas R. Multiplexed monitoring of a novel autoantibody diagnostic signature of colorectal cancer using HaloTag technology-based electrochemical immunosensing platform. Theranostics 2020; 10(7):3022-3034.
DOITumor suppressor ARF regulates tissue microenvironment and tumorgrowth through modulation of macrophage polarization Oncotarget
L Jiménez-García; S Herranz; MA Higueras; (AC); A Luque; S Hortelano. 2016. Tumor suppressor ARF regulates tissue microenvironment and tumorgrowth through modulation of macrophage polarization Oncotarget. 2016 Oct 11;7(41):66835-66850. https://doi.org/10.18632/oncotarget.11652.
DOIAβ42 Peptide Promotes Proliferation and Gliogenesis in Human Neural Stem Cells
Aβ42 Peptide Promotes Proliferation and Gliogenesis in Human Neural Stem Cells. Bernabeu-Zornoza A, Coronel R, Palmer C, Calero M, Martínez-Serrano A, Cano E, Zambrano A, Liste I. Mol Neurobiol. 2019 Jun;56(6):4023-4036. doi: 10.1007/s12035-018-1355-7. Epub 2018 Sep 27. PMID: 30259399.
PUBMED DOIImmune profiling of gliomas reveals a connection with Tau function and the tumor vasculature
Cejalvo T*, Gargini R*, Segura-Collar B, Mata P, Herránz B, Cantero D, Ruano Y, García-Pérez D, Pérez-Núñez A, Ramos A, Hernández-Laín A, Cruz Martín-Soberón M, Sánchez-Gómez P# and Sepúlveda-Sánchez JM# (# Co-corresponding author) (* Co-1st author). (2020) Immune profiling of gliomas reveals a connection with Tau function and the tumor vasculature. Cancers. 12-11, pp.E3230. PMID: 33147752doi: 10.3390/cancers12113230
DOIThe complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues
Riesco-Eizaguirre G*, Santisteban P and De la Vieja A*. The complex regulation of NIS expression and activity in thyroid and extrathyroidal tissues. Endocrine-Related Cancer 2021 28(10):T141-T165. PMID: 34387194. doi: 10.1530/ERC-21-0217
DOIInformación adicional
El trabajo de nuestra Unidad se centra en el estudio del comportamiento de los tumores cerebrales, en concreto los gliomas de grado 4, los glioblastomas (GBM), que son tumores muy agresivos y con un índice de supervivencia de unos 12-15 meses. Entre las principales barreras en el tratamiento de estos tumores están su elevada heterogeneidad y su alto nivel de quimioresistencia a los agentes citotóxicos convencionales A pesar de que la cirugía elimine la masa tumoral principal y el paciente sea tratado con radioterapia local y quimioterapia sistémica, los GBM siempre recidivan a partir de las células tumorales que quedan en el cerebro tras la cirugía, siendo responsables de la muerte del paciente. En el laboratorio seguimos un abordaje traslacional para caracterizar la distribución de las células tumorales tanto en el centro del tumor como en las zonas periféricas, así como su interacción con las células del microambiente cerebral, que también participan en la agresividad de estos tumores.
Esquema que muestra la presencia de diferentes microambientes tumorales en el centro tumoral de los glioblastomas (arriba) y en el frente invasivo (periferia) (abajo). Figura generada por Ismael Gacem (@ismael_gacem).
La Unidad colabora estrechamente con expertos clínicos del Hospital 12 de Octubre, lo que nos permite participar en estudios moleculares y celulares con muestras de pacientes (ver como ejemplo la figura de abajo), así como establecer cultivos primarios y alo- y xeno-injertos en modelos murinos. Estos modelos son utilizados en diferentes proyectos de investigación en colaboración con empresas farmacéuticas y con otros equipos de investigación multidisciplinares (matemáticos, ingenieros, bioinformáticos, químicos). Nuestro objetivo final es mejorar las terapias existentes, o bien diseñar estrategias alternativas.
Link a la página web del laboratorio: http://www.gliomalab.com
Redes:
@gliomalab
https://www.linkedin.com/in/pilar-s%C3%A1nchez-g%C3%B3mez-7b571826
https://www.linkedin.com/in/reachglio-project-06506530b/
