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Investigación
Biología Computacional
Líneas de investigación
Contenidos con Investigacion .
Biología Computacional
- Uso de la Biología Computacional para investigación de mecanismos moleculares alterados en enfermedades crónicas (neurodegeneración y cancer) que puedan contribuir a prevenir, diagnosticar precozmente, y tratar la enfermedad de manera individualizada.
- Búsqueda e interpretación de vías de señalización, variantes génicas y genes biomarcadores obtenidos por técnicas de secuenciación profunda y técnicas de genotipado masivo.
Proyectos de investigación
Contenidos con Investigacion .
- 2022-2025: Modelos humanos neurales para estudiar la evolución celular y proteómica en la enfermedad de Alzheimer. PI22/00055. Proyecto de Acción Estratégica en Salud Intramural. PI I Liste, CoIP V. López-Alonso.
- 2022-2024: CAM Ayudas para la contratación de técnico de Garantia Juvenil
- 2022-2025: Medicina Personalizada (MedPer) en la detección precoz del deterioro cognitivo (DC) preclínico. Desarrollo de un modelo predictivo de riesgo. PMP22/00084. Proyectos de Investigación de Medicina Personalizada de Precisión de la Acción Estratégica en Salud. IP. A. Almeida Parra.
- 2022-2025: Implicaciones de la proteína precursora amiloide (APP): neurodesarrollo y enfermedad de Alzheimer. PID2021-126715OB-I00. Programa Estatal de I+D+i Orientada a los Retos de la Sociedad. Ministerio de Ciencia e Innovación. PI I. Liste
- From 2017-2022. Project MinE International groundbreaking genetic ALS research (www.projectmine.com).
- 2020 – 2022: ELA-BASE: Una cohorte para un estudio piloto longitudinal de Medicina de Precisión en Esclerosis Lateral Amiotrófica (ELA). UFIECPY 354/19-TS.Actividad Singular dentro del Programa de prestación de servicios científico-técnicos en los centros del ISCIII. Programa Intramural 2019 ISCIII. PI Y. Campos.
- 2020–2021: Spanish Ministry of Economy and Competitiveness: Ayudas para la contratación de estudiantes, Garantia Juvenil. V. López-Alonso
- 01/04/2015 - 01/04/2021: New therapeutic strategies for resistant colorectal cancer. Fundación Científica de la Asociación Española Contra el Cáncer. CGB14142035THOM. PI JM Rojas.
- 2017-2020: MicroRNAs y marcadores de metabolismo lipídico como potencial enlace entre la disfunción vascular y la patofisiología de la enfermedad de Alzheimer. SAF2016-78603-R MINECO. PI M Medina.
- 2017-2020: Papel fisiológico de la proteína Shoc2/Sur8 y estudio de su implicación en patologías humanas. SAF2016-78852-R MINECO. PI JM Rojas.
- 2019: Proyecto MinE: del análisis biocomputacional de genomas de pacientes con Esclerosis Lateral Amiotrófica al desarrollo de un modelo de motoneurona diferenciada a partir de células madre pluripotenciales inducidas obtenidas de cultivos de fibroblastos humanos de origen dérmico. GGVP 345/18 FUNDELA. IP Y Campos.
- 2011-2013. IMBIOMEDvision: Promoting and Monitoring Biomedical Informatics in Europa Grant agreement no: 270107 Comisión Europea. IP V López-Alonso
- 2011-2012. COMBIOMED. Red Temática de Investigación Cooperativa en Biomedicina Computacional RD07/0067/00 Fondo de Investigación Sanitaria. Instituto de Salud Carlos III. IP y Coordinación V. López-Alonso
Publicaciones destacadas
Survival Patterns of Human Prion Diseases in Spain, 1998-2018: Clinical Phenotypes and Etiological Clues
Tejedor-Romero L, López-Cuadrado T, Almazán-Isla J, Calero M, García López FJ, de Pedro-Cuesta J. Survival Patterns of Human Prion Diseases in Spain, 1998-2018: Clinical Phenotypes and Etiological Clues. Front Neurosci. 2022 15:773727. doi: 10.3389/fnins.2021.773727. eCollection 2021.
DOIATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization
Tazelaar GHP, Boeynaems S, De Decker M, van Vugt J, Kool L, Goedee HS, et al. ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization. Brain Commun. 2020,2(2):fcaa064. Q1
Magnetic microbeads-based amperometric immunoplatform for the rapid and sensitive detection of N6-methyladenosine to assist in metastatic cancer cells discrimination
Eloy Povedano, María Gamella, Rebeca M. Torrente-Rodríguez, Ana Montero-Calle, María Pedrero, Guillermo Solís-Fernández, Fernando Navarro-Villoslada, Rodrigo Barderas, Susana Campuzano, José M. Pingarrón. Magnetic microbeads-based amperometric immunoplatform for the rapid and sensitive detection of N6-methyladenosine to assist in metastatic cancer cells discrimination. Biosensors and Bioelectronics. 2021; 171:112708
DOISOS GEFs in health and disease
Baltanás FC, Zarich N, Rojas- Cabañeros JM & Santos E. SOS GEFs in health and disease. BBA-Reviews on Cancer. 2020; 188445. doi: 10.1016/j.bbcan.2020.188445
DOIThyroid hormone increases bulk histones expression by enhancing translational efficiency
Thyroid hormone increases bulk histones expression by enhancing translational efficiency. Zambrano A, García-Carpizo V, Villamuera R, Aranda A. Mol Endocrinol. 2015 Jan;29(1):68-75. doi: 10.1210/me.2014-1235. PMID: 25422881; PMCID: PMC5414774.
PUBMED DOIEpidemiological bases and molecular mechanisms linking obesity, diabetes, and cancer
Gutiérrez-Salmerón M, Chocarro-Calvo A, García-Martínez JM, de la Vieja A, García-Jiménez C. Epidemiological bases and molecular mechanisms linking obesity, diabetes, and cancer. Endocrinol Diabetes Nutr. 2017 Feb; 64(2):109-117. (https://www.ncbi.nlm.nih.gov/pubmed/28440775) doi:10.1016/j.endinu.2016.10.005
PUBMED DOISalivary lactoferrin as biomarker for Alzheimer's disease: Brain-immunity interactions
Bermejo-Pareja F, Del Ser T, Valentí M, de la Fuente M, Bartolome F, Carro E. Salivary lactoferrin as biomarker for Alzheimer's disease: Brain-immunity interactions. Alzheimers Dement. 2020 Aug;16(8):1196-1204. doi: 10.1002/alz.12107.
DOIOcoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma
Hernández SanMiguel, E.; Gargini, R.; Cejalvo, T., Segura-Collar B, Núñez-Hervada P, Hortigüela R, Sepúlveda-Sánchez JM, Hernández-Laín A, Pérez-Núñez A, Sanz E, Sánchez Gómez, P. (2019) Ocoxin Modulates Cancer Stem Cells and M2 Macrophage Polarization in Glioblastoma. Oxid.Med.Cell. Longev. pp.9719730. PMID: 31467641. doi: 10.1155/2019/9719730
DOIImpact of environmental neurotoxic: current methods and usefulness of human stem cells
Rosca, A.; Coronel, R.; Moreno, M.; González, R.; Oniga, A.; Martín, A.; López, V.; González, M.C.; Liste, I. (2020). Impact of environmental neurotoxic: current methods and usefulness of human stem cells. Heliyon. 6, e05773. doi: 10.1016/j.heliyon.2020.e05773.
DOIGenomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study
de Rojas I, Hernández I, Montrreal L, Quintela I, Calero M, Royo JL, Huerto Vilas R, González-Pérez A, Franco-Macías E, Macías J, Menéndez-González M, Frank-García A, Diez-Fairen M, Lage C, García-Madrona S, Aguilera N, García-González P, Puerta R, Sotolongo-Grau O, Alonso-Lana S, Rábano A, Arias Pastor A, Pastor AB, Corma-Gómez A, Martín Montes A, Martínez Rodríguez C, Buiza-Rueda D, Periñán MT, Rodriguez-Rodriguez E, Alvarez I, Rosas Allende I, Pineda JA, Bernal Sánchez-Arjona M, Fernández-Fuertes M, Mendoza S, Del Ser T, Gr Ace/Degesco Consortium, Garcia-Ribas G, Sánchez-Juan P, Pastor P, Bullido MJ, Álvarez V, Real LM, Mir P, Piñol-Ripoll G, García-Alberca JM, Medina M, Orellana A, Butler CR, Marquié M, Sáez ME, Carracedo Á, Tárraga L, Boada M, Ruiz A. Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study. J Pers Med. 2021 11(12):1318. doi: 10.3390/jpm11121318.
DOIImpact of environmental neurotoxic: current methods and usefulness of human stem cells
Rosca A, Coronel R, Moreno M, Gonzalez R, Oniga A, Martin A, et al. Impact of environmental neurotoxic: current methods and usefulness of human stem cells. Heliyon. 2020,6(12):e05773. Q1
Bringing to Light the Importance of the miRNA Methylome in Colorectal Cancer Prognosis Through Electrochemical Bioplatforms
Povedano E, Ruiz-Valdepeñas Montiel V, Sebuyoya R, Torrente-Rodríguez RM, Garranzo-Asensio M, Montero-Calle A, Pingarrón JM, Barderas R, Bartosik M, Campuzano S. Bringing to Light the Importance of the miRNA Methylome in Colorectal Cancer Prognosis Through Electrochemical Bioplatforms. Analytical Chemistry 2024;96:4580
DOIMinilungs from Human Embryonic Stem Cells to Study the Interaction of Streptococcus pneumoniae with the Respiratory Tract
Sempere J, Rossi SA, Chamorro-Herrero I, González-Camacho F, de Lucas MP, Rojas-Cabañeros JM, Taborda CP, Zaragoza O, Yuste J & Zambrano A. Minilungs from Human Embryonic Stem Cells to Study the Interaction of Streptococcus pneumoniae with the Respiratory Tract. Microbiology Spectrum. 2022; 10(3):e00453-22. doi: 10.1128/spectrum.00453-22
DOIThe thyroid hormone receptor β induces DNA damage and premature senescence
The thyroid hormone receptor β induces DNA damage and premature senescence. Zambrano A, García-Carpizo V, Gallardo ME, Villamuera R, Gómez-Ferrería MA, Pascual A, Buisine N, Sachs LM, Garesse R, Aranda A. J Cell Biol. 2014 Jan 6;204(1):129-46. doi: 10.1083/jcb.201305084. PMID: 24395638; PMCID: PMC3882795.
PUBMED DOIFrom obesity to diabetes and cancer: epidemiological links and role of therapies
García-Jiménez C, Gutiérrez-Salmerón M, Chocarro-Calvo A, García-Martínez JM, Castaño A, De la Vieja A. From obesity to diabetes and cancer: epidemiological links and role of therapies. Br J Cancer. 2016 Mar 29; 114(7):716-22. (https://www.ncbi.nlm.nih.gov/pubmed/26908326) doi: 10.1038/bjc.2016.37
PUBMED DOIAquaporin 5 in Alzheimer's disease: a link between oral and brain pathology?
Municio C, Carro E. Aquaporin 5 in Alzheimer's disease: a link between oral and brain pathology? Neural Regen Res. 2023 Jul;18(7):1491-1492. doi: 10.4103/1673-5374.361545.
DOIThe Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration
Villanueva AA, Falcón P, Espinoza N, R LS, Milla LA, Hernández-SanMiguel E, Torres VA, Sanchez-Gomez P, Palma V. (2017) The Netrin-4/ Neogenin-1 axis promotes neuroblastoma cell survival and migration. Oncotarget 8(6):9767-9782. PMID: 28038459 doi: 18632/oncotarget.14213
DOIAnalysis of Benzalkonium Chloride Resistance and Potential Virulence of Listeria monocytogenes Isolates Obtained from Different Stages of a Poultry Production Chain in Spain
Lopez-Alonso V, Ortiz S, Corujo A, Martinez-Suarez JV. Analysis of Benzalkonium Chloride Resistance and Potential Virulence of Listeria monocytogenes Isolates Obtained from Different Stages of a Poultry Production Chain in Spain. J Food Prot. 2020,83(3):443-51. Q2
Physiological and pathological effects of amyloid-β species in neural stem cell biology
Bernabeu-Zornoza, A.; Coronel, R.; Palmer, C.; Monteagudo, M.; Zambrano, A.; Liste, I. (2019). Physiological and pathological effects of amyloid-β species in neural stem cell biology. Neural Regen Res. 14, 2035-2042. doi: 10.4103/1673-5374.262571.
DOISelenium Increases Thyroid-Stimulating Hormone-Induced Sodium/Iodide Symporter Expression Through Thioredoxin/Apurinic/Apyrimidinic Endonuclease 1-Dependent Regulation of Paired Box 8 Binding Activity. Antioxid Redox Signal. 2016 May 20; 24(15):855-66. (*co-corresponding authors) (IF: 6,337)
Leoni SG, Sastre-Perona A, De la Vieja A, Santisteban P. Selenium Increases Thyroid-Stimulating Hormone-Induced Sodium/Iodide Symporter Expression Through Thioredoxin/Apurinic/Apyrimidinic Endonuclease 1-Dependent Regulation of Paired Box 8 Binding Activity. Antioxid Redox Signal. 2016 May 20; 24(15):855-66. (https://www.ncbi.nlm.nih.gov/pubmed/26908326) doi: 10.1089/ars.2014.6228
PUBMED DOIUnraveling autoimmune and neurodegenerative diseases by amperometric serological detection of antibodies against aquaporin-4
Arévalo B, Blázquez M, Serafín V, Montero-Calle A, Calero M, Valverde A, Barderas R, Campuzano S, Yáñez-Sedeño P, Pingarrón JM. Unraveling autoimmune and neurodegenerative diseases by amperometric serological detection of antibodies against aquaporin-4. Bioelectrochemistry. 2021 144:108041. doi: 10.1016/j.bioelechem.2021.108041.
DOISpatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis
Solís-Fernández G, Montero-Calle A, Martínez-Useros J, López-Janeiro Á, de los Ríos V, Sanz R, Dziakova J, Milagrosa E, Fernández-Aceñero MJ, Peláez-García A, et al. Spatial Proteomic Analysis of Isogenic Metastatic Colorectal Cancer Cells Reveals Key Dysregulated Proteins Associated with Lymph Node, Liver, and Lung Metastasis. Cells. 2022; 11(3):447
DOIPKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability
Martínez N, Gragera T, de Lucas MP, Cámara AB, Ballester A, Anta B, Fernández-Medarde A, López-Briones T, Ortega J, Peña-Jiménez D, Barbáchano A, Montero-Calle A, Cordero V, Barderas R, Iglesias T, Yunta M, Oliva JL, Muñoz A, Santos E, Zarich N & Rojas-Cabañeros JM. PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability. Oncogenesis. 2023; 12:20. doi.org/10.1038/s41389-023-00465-3
DOIDecreased salivary lactoferrin levels are specific to Alzheimer's disease
González-Sánchez M, Bartolome F, Antequera D, Puertas-Martín V, González P, Gómez-Grande A, Llamas-Velasco S, Herrero-San Martín A, Pérez-Martínez D, Villarejo-Galende A, Atienza M, Palomar-Bonet M, Cantero JL, Perry G, Orive G, Ibañez B, Bueno H, Fuster V, Carro E. Decreased salivary lactoferrin levels are specific to Alzheimer's disease. EBioMedicine. 2020 Jul;57:102834. doi: 10.1016/j.ebiom.2020.102834.
DOIApplied mathematics and nonlinear sciences in the war on cancer
Pérez-García VM, Fitzpatrick S, Pérez-Romasanta LA, Pesic M, Schucht P, Arana E, Sánchez-Gómez P. (2016) Applied mathematics and nonlinear sciences in the war on cancer. App. Math. Nonlin. Sci. 1(2): 423–436 doi: 10.21042/AMNS.2016.2.00036
DOIPhysiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved
Coronel, R.; Palmer, C.; Bernabeu-Zornoza, A.; Monteagudo, M.; Rosca, A.; Zambrano, A.; Liste, I. (2019). Physiological effects of amyloid precursor protein and its derivatives on neural stem cell biology and signaling pathways involved. Neural Regen Res. 14, 1661-1671. doi: 10.4103/1673-5374.257511.
DOIInsulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin
García-Martínez JM, Chocarro-Calvo A, De la Vieja A, García-Jiménez C. Insulin drives glucose-dependent insulinotropic peptide expression via glucose-dependent regulation of FoxO1 and LEF1/β-catenin. Biochim Biophys Acta. 2014 Nov; 1839(11):1141-50. (https://www.ncbi.nlm.nih.gov/pubmed/25091498) doi:10.1016/j.bbagrm.2014.07.020
PUBMED DOIImpaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance
Lopez-Vilaret KM, Cantero JL, Fernandez-Alvarez M, Calero M, Calero O, Lindín M, Zurrón M, Díaz F, Atienza M. Impaired glucose metabolism reduces the neuroprotective action of adipocytokines in cognitively normal older adults with insulin resistance. Aging (Albany NY). 2021 13(21):23936-23952. doi: 10.18632/aging.203668.
DOIThe project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public
van der Spek RAA, van Rheenen W, Pulit SL, Kenna KP, van den Berg LH, Veldink JH, et al. The project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public. Amyotroph Lateral Scler Frontotemporal Degener. 2019,20(5-6):432-40. Q1
Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis
Torres Iglesias G, Fernández-Fournier M, Botella L, Piniella D, Laso-García F, Gómez-de Frutos MC, Chamorro B, Puertas I, Tallón Barranco A, Fuentes B, de Leciñana MA, Alonso-López E, Bravo SB, Miranda-Carús ME, Montero-Calle A, Barderas R, Díez-Tejedor E, Gutiérrez-Fernández M, Otero-Ortega L. Brain and immune system-derived extracellular vesicles mediate regulation of complement system, extracellular matrix remodeling, brain repair and antigen tolerance in Multiple sclerosis. Brain, Behavior, and Immunity. 2023; 113:44
DOISalivary lactoferrin is associated with cortical amyloid-beta load, cortical integrity, and memory in aging
Reseco L, Atienza M, Fernandez-Alvarez M, Carro E, Cantero JL. Salivary lactoferrin is associated with cortical amyloid-beta load, cortical integrity, and memory in aging. Alzheimers Res Ther. 2021 Sep 6;13(1):150. doi: 10.1186/s13195-021-00891-8.
DOIPreclinical test of dacomitinib, an irreversible EGFR inhibitor, confirms its effectiveness for glioblastoma
Zahonero C, Aguilera P, Ramírez-Castillejo C, Pajares M, Bolós MV, Cantero C, Pérez-Núñez A, Hernández-Laín A, Sánchez-Gómez P*, Sepúlveda JM*. (*Co-corresponding authors) (2015) Preclinical test of dacomitinib, an irreversible EGFR inhibitor, confirms its effectiveness for glioblastoma. Mol. Can. Ther. 14(7):1548-58. PMID: 25939761 doi: 10.1158/1535-7163.MCT-14-0736
DOIWhole-Genome Sequences of Seven Listeria monocytogenes Strains from Different Stages of a Poultry Meat Production Chain
Lopez-Alonso V, Ortiz S, Martinez-Suarez JV. Whole-Genome Sequences of Seven Listeria monocytogenes Strains from Different Stages of a Poultry Meat Production Chain. Microbiol Resour Announc. 2019,8(11). Q4
Role of amyloid precursor protein (APP) and its derivatives in the biology and cell fate specification of neural stem cells
Coronel, R.; Bernabeu-Zornoza, A.; Palmer, C.; Muñiz-Moreno, M.; Zambrano, A.; Cano, E.; Liste, I. (2018). Role of amyloid precursor protein (APP) and its derivatives in the biology and cell fate specification of neural stem cells. Mol Neurobiol. 55, 7107-7117. doi: 10.1007/s12035-018-0914-2.
DOIMedial Temporal Lobe Involvement in Human Prion Diseases: Implications for the Study of Focal Non Prion Neurodegenerative Pathology
Rábano A, Guerrero Márquez C, Juste RA, Geijo MV, Calero M. Medial Temporal Lobe Involvement in Human Prion Diseases: Implications for the Study of Focal Non Prion Neurodegenerative Pathology. Biomolecules. 2021 Mar 10;11(3):413. doi: 10.3390/biom11030413.
DOIFlat clathrin lattices are linked to metastatic potential in colorectal cancer
Cresens C, Solís-Fernández G, Tiwari A, Nuyts R, Hofkens J, Barderas R, Rocha S. Flat clathrin lattices are linked to metastatic potential in colorectal cancer. iScience. 2023; 26: 107327
DOINIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer
Riesco-Eizaguirre G, Leoni SG, Mendiola M, Estévez-Cebrero MA, Gallego MI, Redondo A, Hardisson D, Santisteban P, De la Vieja A. NIS mediates iodide uptake in the female reproductive tract and is a poor prognostic factor in ovarian cancer. J Clin Endocrinol Metab. 2014 Jul; 99(7):E1199-208. (https://www.ncbi.nlm.nih.gov/pubmed/24708099) doi: 10.1210/jc.2013-4249
PUBMED DOIStandardizing salivary lactoferrin measurements to obtain a robust diagnostic biomarker for Alzheimer's disease
Bartolome F, Orive G, Carro E. Standardizing salivary lactoferrin measurements to obtain a robust diagnostic biomarker for Alzheimer's disease. Alzheimers Dement (Amst). 2021 May 2;13(1):e12173. doi: 10.1002/dad2.12173.
DOIControlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma
González-Gómez P, Crecente-Campo J, Zahonero C, de la Fuente M, Hernández-Laín A, Mira H*, Sánchez-Gómez P*, García-Fuentes M* (* Co-corresponding authors). (2015) Controlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma. Oncotarget, 6 (13): 10950-10963. PMID: 25860932 doi: 10.18632/oncotarget.3459
DOIAdvances in Alzheimer’s disease research: Human cerebral organoids
Mateos-Martínez, P.; González-Sastre, R.; Coronel, R.; Rosca, A.; Martín-Benito, S.; Bernabeu-Zornoza, A.; López-Alonso, V.; Liste, I. (2023). Advances in Alzheimer’s disease research: Human cerebral organoids. Am J Biomed Sci & Res. 18, AJBSR.MS.ID.002421. doi: 10.34297/AJBSR.2023.18.002421.
DOIValidation of a novel and accurate ApoE4 assay for automated chemistry analyzers
Veiga S, Rodríguez-Martín A, Garcia-Ribas G, Arribas I, Menacho-Román M, Calero M. Validation of a novel and accurate ApoE4 assay for automated chemistry analyzers. Sci Rep. 2020 10(1):2138. doi: 10.1038/s41598-020-58841-7.
DOIAdvances in Alzheimer’s Disease Research: Human Cerebral Organoids
Mateos P., González R., Coronel R., Rosca A, Martín S., Bernabeu A, López-Alonso V and Liste I. Advances in Alzheimer’s Disease Research: Human Cerebral Organoids. American Journal of Biomedical Science & Research. 2023; 715:719.
Multiomics Profiling of Alzheimer’s Disease Serum for the Identification of Autoantibody Biomarkers
San Segundo-Acosta P, Montero-Calle A, Jernbom-Falk A, Alonso-Navarro M, Pin E, Andersson E, Hellström C, Sánchez-Martínez M, Rábano A, Solís-Fernández G, Peláez-García A, Martínez-Useros J, Fernández-Aceñero MJ, Månberg A, Nilsson P, Barderas R. Multiomics Profiling of Alzheimer’s Disease Serum for the Identification of Autoantibody Biomarkers. Journal of Proteome Research 2021 20 (11), 5115-5130.
DOIKynurenic Acid Levels are Increased in the CSF of Alzheimer's Disease Patients
González-Sánchez M, Jiménez J, Narváez A, Antequera D, Llamas-Velasco S, Martín AH, Arjona JAM, Munain AL, Bisa AL, Marco MP, Rodríguez-Núñez M, Pérez-Martínez DA, Villarejo-Galende A, Bartolome F, Domínguez E, Carro E. Kynurenic Acid Levels are Increased in the CSF of Alzheimer's Disease Patients. Biomolecules. 2020 Apr 8;10(4):571. doi: 10.3390/biom10040571.
DOIEGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy
Zahonero C and Sánchez-Gómez P. (2014) EGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy. Cel. Mol. Life Sci. 71 (18): 3465-88. PMID: 24671641 doi: 10.1007/s00018-014-1608-1
DOIWorking Group on Disorders Related to Iodine Deficiency and Thyroid Dysfunction of the Spanish Society of Endocrinology and Nutrition. Iodine supplementation during pregnancy and lactation. Position statement of the working group on disorders related to iodine deficiency and thyroid dysfunction of the Spanish Society of Endocrinology and Nutrition
Donnay S, Arena J, Lucas A, Velasco I, Ares S; Working Group on Disorders Related to Iodine Deficiency and Thyroid Dysfunction of the Spanish Society of Endocrinology and Nutrition.. Iodine supplementation during pregnancy and lactation. Position statement of the working group on disorders related to iodine deficiency and thyroid dysfunction of the Spanish Society of Endocrinology and Nutrition. Endocrinol Nutr. 2014 Jan; 61(1):27-34. (https://www.ncbi.nlm.nih.gov/pubmed/24035326) doi:10.1016/j.endonu.2013.05.004
PUBMED DOITreatment of Parkinson’s disease using human stem cells
Palmer, C.; Coronel, R.; Liste, I. (2016). Treatment of Parkinson’s disease using human stem cells. J Stem Cell Res Med. 1, 71-77. doi: 10.15761/JSCRM.1000113.
DOISpanish CJD Surveillance Group. Human prion disease surveillance in Spain, 1993-2018: an overview
De Pedro-Cuesta J, Almazán-Isla J, Tejedor-Romero L, Ruiz-Tovar M, Avellanal F, Rábano A, Calero M, García López FJ; Spanish CJD Surveillance Group. Human prion disease surveillance in Spain, 1993-2018: an overview. Prion. 2021. 15(1):94-106. doi: 10.1080/19336896.2021.1933873.
DOIHuman neural stem cells in developmental neurotoxicology: Current scenario and future prospects. Alternative Methods in Neurotoxicology
Rosca A., Coronel R., López-Alonso V, Liste I, González-Caballero M. Carmen. Human neural stem cells in developmental neurotoxicology: Current scenario and future prospects. Alternative Methods in Neurotoxicology. Advances in Neurotoxicology. 2023; 197:226.
In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression
Montero-Calle A, López-Janeiro Á, Mendes ML, Perez-Hernandez D, Echevarría I, Ruz-Caracuel I, Heredia-Soto V, Mendiola M, Hardisson D, Argüeso P, Peláez-García A, Guzman-Aranguez A, Barderas R. In-depth quantitative proteomics analysis revealed C1GALT1 depletion in ECC-1 cells mimics an aggressive endometrial cancer phenotype observed in cancer patients with low C1GALT1 expression. Cell Oncol. 46, 697–715 (2023).
DOIAnnexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer's disease
Bartolome F, Krzyzanowska A, de la Cueva M, Pascual C, Antequera D, Spuch C, Villarejo-Galende A, Rabano A, Fortea J, Alcolea D, Lleo A, Ferrer I, Hardy J, Abramov AY, Carro E. Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer's disease. Sci Rep. 2020 Jun 10;10(1):9391. doi: 10.1038/s41598-020-66177-5.
DOIA new link between diabetes and cancer: enhanced Wnt/beta-catening signaling by high glucose
García-Jiménez C, Garcia-Martinez JM, Chocarro-Calvo A, and De la Vieja A. A new link between diabetes and cancer: enhanced Wnt/beta-catening signaling by high glucose. Journal of Molecular Endocrinology 2014 52(1): R51-R66. (https://www.ncbi.nlm.nih.gov/pubmed/24049067) doi: 10.1530/JME-13-0152
PUBMED DOIDYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth
Pozo Zahonero, Fernández P, Liñares JM, Ayuso A, Hagiwara M, Pérez A, Ricoy JR, Hernández-Laín A, Sepúlveda JM, Sánchez-Gómez P. (2013) Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth. J. Clin. Invest. 123(6):2475-87. PMID: 23635774 doi: 10.1172/JCI63623
DOIGenetic Diversity, Antimicrobial Resistance and Survival upon Manure Storage of Campylobacter jejuni Isolated from Dairy Cattle Farms in the Cantabric Coast of Spain
Varsaki, A.; Ortiz, S.; Santorum, P.; López, P.; López-Alonso, V.; Martínez-Suárez, J.V. Genetic Diversity, Antimicrobial Resistance and Survival upon Manure Storage of Campylobacter jejuni Isolated from Dairy Cattle Farms in the Cantabric Coast of Spain. Zoonotic Dis. 2022, 2, 82–94
Alzheimer’s Disease Neuroimaging Initiative. Long runs of homozygosity are associated with Alzheimer's disease
Moreno-Grau S, Fernández MV, de Rojas I, Garcia-González P, Hernández I, Farias F, Budde JP, Quintela I, Madrid L, González-Pérez A, Montrreal L, Alarcón-Martín E, Alegret M, Maroñas O, Pineda JA, Macías J; GR@ACE study group; DEGESCO consortium, Marquié M, Valero S, Benaque A, Clarimón J, Bullido MJ, García-Ribas G, Pástor P, Sánchez-Juan P, Álvarez V, Piñol-Ripoll G, García-Alberca JM, Royo JL, Franco-Macías E, Mir P, Calero M, Medina M, Rábano A, Ávila J, Antúnez C, Real LM, Orellana A, Carracedo Á, Sáez ME, Tárraga L, Boada M, Cruchaga C, Ruiz A; Alzheimer’s Disease Neuroimaging Initiative. Long runs of homozygosity are associated with Alzheimer's disease. Transl Psychiatry. 2021 11(1):142. doi: 10.1038/s41398-020-01145-1.
DOIEndothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge
Bartolome F, Antequera D, de la Cueva M, Rubio-Fernandez M, Castro N, Pascual C, Camins A, Carro E. Endothelial-specific deficiency of megalin in the brain protects mice against high-fat diet challenge. J Neuroinflammation. 2020 Jan 14;17(1):22. doi: 10.1186/s12974-020-1702-2.
DOIPursuing precision in medicine and nutrition: the rise of electrochemical biosensing at the molecular level
Campuzano S, Barderas R, Moreno-Casbas MT, Almeida A. Pursuing precision in medicine and nutrition: the rise of electrochemical biosensing at the molecular level. Anal Bioanal Chem 416, 2151–2172 (2024)
DOIGlucose-Induced b-Catenin Acetylation Enhances Wnt Signaling in Cancer
Chocarro-Calvo A, Garcia-Martinez JM, Ardila-González S, De la Vieja A and García-Jiménez C*. Glucose-Induced b-Catenin Acetylation Enhances Wnt Signaling in Cancer. Molecular Cell 2013 49(3):474-486. PMID: 23273980. doi: 10.1016/j.molcel.2012.11.022
DOIExperimental Radiation System for Effects Assessment in Biological in Vitro and in Vivo Models
V. Ramos, P. Marina, M. Torres-Ruiz, O. J. Suárez, V. López, I. Liste, M. de Alba. "Experimental Radiation System for Effects Assessment in Biological in Vitro and in Vivo Models," 2021 Photonics & Electromagnetics Research Symposium (PIERS), 2021, pp. 2800-2807, doi: 10.1109/PIERS53385.2021.9695112
DOITREM2 expression in the brain and biological fluids in prion diseases
Diaz-Lucena D, Kruse N, Thüne K, Schmitz M, Villar-Piqué A, da Cunha JEG, Hermann P, López-Pérez Ó, Andrés-Benito P, Ladogana A, Calero M, Vidal E, Riggert J, Pineau H, Sim V, Zetterberg H, Blennow K, Del Río JA, Marín-Moreno A, Espinosa JC, Torres JM, Sánchez-Valle R, Mollenhauer B, Ferrer I, Zerr I, Llorens F. TREM2 expression in the brain and biological fluids in prion diseases. Acta Neuropathol. 2021 141(6):841-859. doi: 10.1007/s00401-021-02296-1.
DOIContenidos con Investigacion .
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Victoria López Alonso
Responsable de la Unidad de Biología Computacional. Científico Titular ISCIII
Código ORCID: 0000-0001-8129-8352
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Laura Maeso Cuesta
Unidad de Biología Computacional. Técnico de Laboratorio (Contrato PEJ-2021-TL/BMD-21001). Instituto de Salud Carlos III
Código ORCID: https://orcid.org/0009-0007-7453-255
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Rosa González Sastre
Investigadora Predoctoral (Contrato Asociado a Proyecto PID2021-126715OB-100)
Código ORCID: 0000-0003-2503-551X
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Patricia Mateos Martínez
Investigadora Predoctoral (Contrato PFIS-ISCIII)
Código ORCID: 0000-0001-9293-9100
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Diego Suárez
Trabajo Fin de Máster
Listado de personal
Información adicional
La Unidad de Biología Computacional de la UFIEC tiene como línea de investigación principal la aplicación de métodos computacionales para la interpretación funcional de los datos obtenidos por las tecnologías de alto rendimiento, y la posibilidad de integración de esta información con los datos clínicos para aplicaciones diagnósticas y terapéuticas de enfermedades crónicas.
Noticias:
Sesiones comunicativas del grupo:
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11/2021. II Jornadas Científicas de la Escuela Internacional de Doctorado de la UNED (EIDUNED). Programa de Doctorado en Ciencias Biomédicas y Salud Pública UNED-IMIENS. Charla de Rosa González Sastre. https://repisalud.isciii.es/handle/20.500.12105/13766
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09/2022. II Jornada de Seguimiento del Programa de Doctorado en Ciencias Biomédicas y Salud Pública del ISCIII y la UNED. Charla de Patricia Mateos Martínez. https://repisalud.isciii.es/handle/20.500.12105/15119
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24/10/2022. IV Jornada Programa de Mentores del ISCIII. Charlas de Rosa González Sastre y Patricia Mateos Martínez. https://repisalud.isciii.es/handle/20.500.12105/15224
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22/06/2023. Jornada de encuentro del Programa de Doctorado en Ciencias Biomédicas y Salud Pública IMIENS-UNED-ISCIII. Charlas de Rosa González Sastre y Patricia Mateos Martínez. https://repisalud.isciii.es/handle/20.500.12105/16495
- 10/2023. III Jornada de Seguimiento del Programa de Doctorado en Ciencias Biomédicas y Salud Pública del ISCIII y la UNED. Charla de Sabela Martin-Benito https://repisalud.isciii.es/handle/20.500.12105/16871